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Literature summary extracted from

  • Matthews, R.; Bobbie, H.
    Inhibition of pig liver methylenetetrahydrofolate reductase by dihydrofolate some mechanistic and regulatory implications (1979), Biochemistry, 18, 4845-4851 .
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.5.1.53 5,10-methylenetetrahydrofolate substrate inhibition Sus scrofa
1.5.1.53 5-methyl-5,6-dihydrofolate
-
 Sus scrofa
1.5.1.53 dihydrofolate competitive with respect to methylenetetrahydrofolate Sus scrofa
1.5.1.53 folic acid
-
 Sus scrofa
1.5.1.53 methenyltetrahydrofolate
-
 Sus scrofa
1.5.1.53 methyltetrahydrofolate
-
 Sus scrofa
1.5.1.53 tetrahydrofolate
-
 Sus scrofa

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.5.1.53 0.016
-
 NADPH pH 6.7, 25°C Sus scrofa

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.5.1.53 5,10-methylenetetrahydrofolate + NADPH + H+ Sus scrofa
-
 5-methyltetrahydrofolate + NADP+
-
 ?
1.5.1.53 5-methyltetrahydrofolate + oxidized menadione Sus scrofa
-
 5,10-methylenetetrahydrofolate + reduced menadione
-
 ?
1.5.1.53 additional information Sus scrofa no substrate: dihydrofolate ?
-
-

Organism

EC Number Organism UniProt Comment Textmining
1.5.1.53 Sus scrofa
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.5.1.53 liver
-
 Sus scrofa
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.5.1.53 5,10-methylenetetrahydrofolate + NADPH + H+
-
 Sus scrofa 5-methyltetrahydrofolate + NADP+
-
 ?
1.5.1.53 5-methyltetrahydrofolate + oxidized menadione
-
 Sus scrofa 5,10-methylenetetrahydrofolate + reduced menadione
-
 ?
1.5.1.53 additional information no substrate: dihydrofolate Sus scrofa ?
-
-

Cofactor

EC Number Cofactor Comment Organism Structure
1.5.1.53 FAD
-
 Sus scrofa
1.5.1.53 NADPH
-
 Sus scrofa

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.5.1.53 0.006
-
 dihydrofolate pH 6.7, 25°C Sus scrofa

General Information

EC Number General Information Comment Organism
1.5.1.53 metabolism enzyme exhibits ping-pong bi-bi kinetics Sus scrofa