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Literature summary extracted from

  • Park, T.J.; Reznick, J.; Peterson, B.L.; Blass, G.; Omerbasic, D.; Bennett, N.C.; Kuich, P.H.J.L.; Zasada, C.; Browe, B.M.; Hamann, W.; Applegate, D.T.; Radke, M.H.; Kosten, T.; Lutermann, H.; Gavaghan, V.; Eigenbrod, O.; Begay, V.; Amoroso, V.G.; Govind, V.; Minshall, R.D.; Smith, E.S.J.; Larson, J.; Gotthard, M.
    Fructose-driven glycolysis supports anoxia resistance in the naked mole-rat (2017), Science, 356, 307-311 .
    View publication on PubMed

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.1.3 ATP + D-fructose Heterocephalus glaber fructose enters glycolytic metabolism after phosphorylation by ketohexokinase and is converted to fructose-1-phosphate. Fructose-driven glycolytic respiration in Heterocephalus glaber tissues avoids feedback inhibition of glycolysis via phosphofructokinase, allowing continued glycolytic flux independent of cellular energy status and supporting viability ADP + D-fructose 1-phosphate
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 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.3 Heterocephalus glaber
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-
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Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.3 brain
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 Heterocephalus glaber
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2.7.1.3 heart
-
 Heterocephalus glaber
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2.7.1.3 liver
-
 Heterocephalus glaber
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.3 ATP + D-fructose fructose enters glycolytic metabolism after phosphorylation by ketohexokinase and is converted to fructose-1-phosphate. Fructose-driven glycolytic respiration in Heterocephalus glaber tissues avoids feedback inhibition of glycolysis via phosphofructokinase, allowing continued glycolytic flux independent of cellular energy status and supporting viability Heterocephalus glaber ADP + D-fructose 1-phosphate
-
 ?
2.7.1.3 ATP + D-fructose
-
 Heterocephalus glaber ADP + D-fructose 1-phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.1.3 KHK
-
 Heterocephalus glaber
2.7.1.3 Khk-A less efficient KHK-A isoform Heterocephalus glaber
2.7.1.3 Khk-C fructose selective KHK-C isoform Heterocephalus glaber

General Information

EC Number General Information Comment Organism
2.7.1.3 metabolism fructose-driven glycolytic respiration in Heterocephalus glaber tissues avoids feedback inhibition of glycolysis via phosphofructokinase, allowing continued glycolytic flux independent of cellular energy status and supporting viability Heterocephalus glaber