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Literature summary extracted from

  • Oki, K.; Lee, F.S.; Mayo, S.L.
    Attempts to develop an enzyme converting DHIV to KIV (2019), Protein Eng. Des. Sel., 32, 261-270 .
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.1.185 recombinant expression of the PtM3K gene under a J23105 promoter Picrophilus torridus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.1.185 Mg2+ required Picrophilus torridus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.1.185 ATP + (R)-mevalonate Picrophilus torridus
-
ADP + (R)-3-phosphomevalonate
-
?
2.7.1.185 ATP + (R)-mevalonate Picrophilus torridus ATCC 700027
-
ADP + (R)-3-phosphomevalonate
-
?
2.7.1.185 ATP + (R)-mevalonate Picrophilus torridus NBRC 100828
-
ADP + (R)-3-phosphomevalonate
-
?
2.7.1.185 ATP + (R)-mevalonate Picrophilus torridus DSM 9790
-
ADP + (R)-3-phosphomevalonate
-
?
2.7.1.185 ATP + (R)-mevalonate Picrophilus torridus JCM 10055
-
ADP + (R)-3-phosphomevalonate
-
?

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.185 Picrophilus torridus Q6KZB1
-
-
2.7.1.185 Picrophilus torridus ATCC 700027 Q6KZB1
-
-
2.7.1.185 Picrophilus torridus DSM 9790 Q6KZB1
-
-
2.7.1.185 Picrophilus torridus JCM 10055 Q6KZB1
-
-
2.7.1.185 Picrophilus torridus NBRC 100828 Q6KZB1
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.185 ATP + (R)-2,3-dihydroxyisovalerate the Picrophilus torridus mevalonate-3-kinase (M3K) exhibits adenosine triphosphate (ATP) hydrolysis activity when mixed with (R)-2,3-dihydroxyisovalerate (DHIV), indicating phosphorylation activity towards DHIV Picrophilus torridus ADP + (R)-2-hydroxy-3-phosphoisovalerate
-
?
2.7.1.185 ATP + (R)-2,3-dihydroxyisovalerate the Picrophilus torridus mevalonate-3-kinase (M3K) exhibits adenosine triphosphate (ATP) hydrolysis activity when mixed with (R)-2,3-dihydroxyisovalerate (DHIV), indicating phosphorylation activity towards DHIV Picrophilus torridus ATCC 700027 ADP + (R)-2-hydroxy-3-phosphoisovalerate
-
?
2.7.1.185 ATP + (R)-2,3-dihydroxyisovalerate the Picrophilus torridus mevalonate-3-kinase (M3K) exhibits adenosine triphosphate (ATP) hydrolysis activity when mixed with (R)-2,3-dihydroxyisovalerate (DHIV), indicating phosphorylation activity towards DHIV Picrophilus torridus NBRC 100828 ADP + (R)-2-hydroxy-3-phosphoisovalerate
-
?
2.7.1.185 ATP + (R)-2,3-dihydroxyisovalerate the Picrophilus torridus mevalonate-3-kinase (M3K) exhibits adenosine triphosphate (ATP) hydrolysis activity when mixed with (R)-2,3-dihydroxyisovalerate (DHIV), indicating phosphorylation activity towards DHIV Picrophilus torridus DSM 9790 ADP + (R)-2-hydroxy-3-phosphoisovalerate
-
?
2.7.1.185 ATP + (R)-2,3-dihydroxyisovalerate the Picrophilus torridus mevalonate-3-kinase (M3K) exhibits adenosine triphosphate (ATP) hydrolysis activity when mixed with (R)-2,3-dihydroxyisovalerate (DHIV), indicating phosphorylation activity towards DHIV Picrophilus torridus JCM 10055 ADP + (R)-2-hydroxy-3-phosphoisovalerate
-
?
2.7.1.185 ATP + (R)-mevalonate
-
Picrophilus torridus ADP + (R)-3-phosphomevalonate
-
?
2.7.1.185 ATP + (R)-mevalonate
-
Picrophilus torridus ATCC 700027 ADP + (R)-3-phosphomevalonate
-
?
2.7.1.185 ATP + (R)-mevalonate
-
Picrophilus torridus NBRC 100828 ADP + (R)-3-phosphomevalonate
-
?
2.7.1.185 ATP + (R)-mevalonate
-
Picrophilus torridus DSM 9790 ADP + (R)-3-phosphomevalonate
-
?
2.7.1.185 ATP + (R)-mevalonate
-
Picrophilus torridus JCM 10055 ADP + (R)-3-phosphomevalonate
-
?
2.7.1.185 additional information a first reaction strategy is the activaion of (R)-2,3-dihydroxyisovalerate (DHIV) to 3-phospho-DHIV using M3K followed by dehydration by PpManR, StPutD or other sugar acid dehydratases. A second strategy is to use M3K and/or mevalonate decarboxylase (MVD) to convert DHIV to isobutyraldehyde, which can be an alternative pathway for isobutanol biosynthesis Picrophilus torridus ?
-
-
2.7.1.185 additional information a first reaction strategy is the activaion of (R)-2,3-dihydroxyisovalerate (DHIV) to 3-phospho-DHIV using M3K followed by dehydration by PpManR, StPutD or other sugar acid dehydratases. A second strategy is to use M3K and/or mevalonate decarboxylase (MVD) to convert DHIV to isobutyraldehyde, which can be an alternative pathway for isobutanol biosynthesis Picrophilus torridus ATCC 700027 ?
-
-
2.7.1.185 additional information a first reaction strategy is the activaion of (R)-2,3-dihydroxyisovalerate (DHIV) to 3-phospho-DHIV using M3K followed by dehydration by PpManR, StPutD or other sugar acid dehydratases. A second strategy is to use M3K and/or mevalonate decarboxylase (MVD) to convert DHIV to isobutyraldehyde, which can be an alternative pathway for isobutanol biosynthesis Picrophilus torridus NBRC 100828 ?
-
-
2.7.1.185 additional information a first reaction strategy is the activaion of (R)-2,3-dihydroxyisovalerate (DHIV) to 3-phospho-DHIV using M3K followed by dehydration by PpManR, StPutD or other sugar acid dehydratases. A second strategy is to use M3K and/or mevalonate decarboxylase (MVD) to convert DHIV to isobutyraldehyde, which can be an alternative pathway for isobutanol biosynthesis Picrophilus torridus DSM 9790 ?
-
-
2.7.1.185 additional information a first reaction strategy is the activaion of (R)-2,3-dihydroxyisovalerate (DHIV) to 3-phospho-DHIV using M3K followed by dehydration by PpManR, StPutD or other sugar acid dehydratases. A second strategy is to use M3K and/or mevalonate decarboxylase (MVD) to convert DHIV to isobutyraldehyde, which can be an alternative pathway for isobutanol biosynthesis Picrophilus torridus JCM 10055 ?
-
-

Synonyms

EC Number Synonyms Comment Organism
2.7.1.185 M3K
-
Picrophilus torridus
2.7.1.185 mevalonate-3-kinase
-
Picrophilus torridus
2.7.1.185 PtM3K
-
Picrophilus torridus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.7.1.185 30
-
assay at Picrophilus torridus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.7.1.185 7.5
-
assay at Picrophilus torridus

General Information

EC Number General Information Comment Organism
2.7.1.185 physiological function the enzyme is specialized as a mevalonate 3-kinase catalyzing the first step of the mevalonate decarboxylation (MVD) reaction Picrophilus torridus