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Literature summary extracted from

  • Layre, E.; Lee, H.J.; Young, D.C.; Martinot, A.J.; Buter, J.; Minnaard, A.J.; Annand, J.W.; Fortune, S.M.; Snider, B.B.; Matsunaga, I.; Rubin, E.J.; Alber, T.; Moody, D.B.
    Molecular profiling of Mycobacterium tuberculosis identifies tuberculosinyl nucleoside products of the virulence-associated enzyme Rv3378c (2014), Proc. Natl. Acad. Sci. USA, 111, 2978-2983 .
    View publication on PubMedView publication on EuropePMC

Application

EC Number Application Comment Organism
2.5.1.153 diagnostics the Mycobacterium tuberculosis-specific lipid 1-tuberculosinyladenosine is a target for diagnosing tuberculosis disease Mycobacterium tuberculosis

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
2.5.1.153 vapor diffusion, and 2.2 A resolution, crystal structure reveals a cis-prenyl transferase fold with hydrophobic residues for isoprenoid binding and a second binding pocket suitable for the nucleoside substrate Mycobacterium tuberculosis

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.5.1.153 tuberculosinyl diphosphate + adenosine Mycobacterium tuberculosis the enzyme produces 1-tuberculosinyladenosine, an abundant amphiphile that is exported outside Mycobacterium tuberculosis 1-tuberculosinyladenosine + diphosphate
-
 ?
2.5.1.153 tuberculosinyl diphosphate + adenosine Mycobacterium tuberculosis ATCC 25618 the enzyme produces 1-tuberculosinyladenosine, an abundant amphiphile that is exported outside Mycobacterium tuberculosis 1-tuberculosinyladenosine + diphosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.5.1.153 Mycobacterium tuberculosis P9WJ61
-
-
2.5.1.153 Mycobacterium tuberculosis ATCC 25618 P9WJ61
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.5.1.153
-
 Mycobacterium tuberculosis

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.5.1.153 tuberculosinyl diphosphate + adenosine the enzyme produces 1-tuberculosinyladenosine, an abundant amphiphile that is exported outside Mycobacterium tuberculosis Mycobacterium tuberculosis 1-tuberculosinyladenosine + diphosphate
-
 ?
2.5.1.153 tuberculosinyl diphosphate + adenosine
-
 Mycobacterium tuberculosis 1-tuberculosinyladenosine + diphosphate
-
 ?
2.5.1.153 tuberculosinyl diphosphate + adenosine the enzyme produces 1-tuberculosinyladenosine, an abundant amphiphile that is exported outside Mycobacterium tuberculosis Mycobacterium tuberculosis ATCC 25618 1-tuberculosinyladenosine + diphosphate
-
 ?
2.5.1.153 tuberculosinyl diphosphate + adenosine
-
 Mycobacterium tuberculosis ATCC 25618 1-tuberculosinyladenosine + diphosphate
-
 ?

Subunits

EC Number Subunits Comment Organism
2.5.1.153 homodimer
-
 Mycobacterium tuberculosis

Synonyms

EC Number Synonyms Comment Organism
2.5.1.153 Rv3378c
-
 Mycobacterium tuberculosis

General Information

EC Number General Information Comment Organism
2.5.1.153 evolution adenosine tuberculosinyltransferase is known only in Mycobacterium tuberculosis. This intersection of nucleoside andterpene pathways likely arose late in the evolution of the Mycobacterium tuberculosis complex Mycobacterium tuberculosis
2.5.1.153 physiological function the extracellular export of the amphipathic molecule 1-tuberculosinyladenosine likely accounts for the known virulence-promoting effects of the Rv3378c enzyme Mycobacterium tuberculosis