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Literature summary extracted from

  • Krishnamoorthy, G.; Kaiser, P.; Lozza, L.; Hahnke, K.; Mollenkopf, H.; Kaufmann, S.
    Mycofactocin is associated with ethanol metabolism in mycobacteria (2019), mBio, 10, e00190 .
    View publication on PubMedView publication on EuropePMC

Organism

EC Number Organism UniProt Comment Textmining
1.3.98.7 Mycolicibacterium smegmatis A0QSB8
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1.3.98.7 Mycolicibacterium smegmatis ATCC 700084 A0QSB8
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1.4.3.26 Mycobacterium marinum
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1.4.3.26 Mycobacterium tuberculosis P9WND7
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1.4.3.26 Mycobacterium tuberculosis H37Rv P9WND7
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1.4.3.26 Mycolicibacterium smegmatis A0QSB9
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1.4.3.26 Mycolicibacterium smegmatis ATCC 700084 A0QSB9
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Synonyms

EC Number Synonyms Comment Organism
1.3.98.7 mftC
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 Mycolicibacterium smegmatis

General Information

EC Number General Information Comment Organism
1.3.98.7 physiological function a MftC deletion mutant is unable to grow in minimal medium containing cholesterol (0.01% [wt/vol]) as the sole carbon source with hot ethanol (1% [vol/vol]) as the solvent (cholesterol and EtOH [cholesterol:EtOH]). There is no significant growth retardation in cholesterol:DMSO. Supplementation of ethanol has no effect on mutant strain growth in propionate (0.5% [wt/vol]) or glycerol (0.2% [vol/vol]) but severely delays mutant strain growth in acetate (0.5% [wt/vol]) in comparison with the growth of the wild-type strain. MftC deletion results in multifold increases in expression of the DosR regulon genes in ethanol-treated strains Mycolicibacterium smegmatis
1.4.3.26 physiological function disruption of any of the genes of the Mft cluster results in impaired growth of Mycobacterium marinum in cholesterol:EtOH. Functionality of Mft is strictly required for growth of free-living mycobacteria in ethanol and other primary alcohols Mycobacterium marinum
1.4.3.26 physiological function disruption of any of the genes of the Mft cluster results in impaired growth of Mycobacterium tuberculosis in cholesterol:EtOH. Functionality of Mft is strictly required for growth of free-living mycobacteria in ethanol and other primary alcohols Mycobacterium tuberculosis
1.4.3.26 physiological function disruption of any of the genes of the Mft cluster results in impaired growth of Mycolicibacterium smegmatis in cholesterol:EtOH. Functionality of Mft is strictly required for growth of free-living mycobacteria in ethanol and other primary alcohols Mycolicibacterium smegmatis