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Literature summary extracted from

  • Persson, B.; Olafsson, O.; Lundgren, H.; Hederstedt, L.; Bjoerk, G.
    The ms2io6A37 modification of tRNA in Salmonella typhimurium regulates growth on citric acid cycle intermediates (1998), J. Bacteriol., 180, 3144-3151 .
    View publication on PubMedView publication on EuropePMC

Organism

EC Number Organism UniProt Comment Textmining
1.14.99.69 Salmonella enterica subsp. enterica serovar Typhimurium Q08015
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.99.69 ms2i6A + reduced acceptor + O2 ms2i6A i.e. N6-(3-methylbut-2-en-1-yl)-2-(methylsulfanyl)adenosine37 in tRNA Salmonella enterica subsp. enterica serovar Typhimurium ms2io6A + acceptor + H2O
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General Information

EC Number General Information Comment Organism
1.14.99.69 physiological function in mutants of MiaE ms2i6A hydroxylation is blocked. Mutant strains are unable to grow aerobically on the dicarboxylic acids of the citric acid cycle, but have normal uptake of dicarboxylic acids and functional enzymes of the citric acid cycle and the aerobic respiratory chain. The ability of S. typhimurium to grow on succinate, fumarate, and malate is dependent on the state of modification in position 37 of those tRNAs normally having ms2io6A37 and is not due to a second cellular function of tRNA (ms2io6A37)hydroxylase, the miaE gene product Salmonella enterica subsp. enterica serovar Typhimurium