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Literature summary extracted from

  • Picard, M.E.; Nisole, A.; Beliveau, C.; Sen, S.; Barbar, A.; Shi, R.; Cusson, M.
    Structural characterization of a lepidopteran type-II farnesyl diphosphate synthase from the spruce budworm, Choristoneura fumiferana Implications for inhibitor design (2018), Insect Biochem. Mol. Biol., 92, 84-92 .
    View publication on PubMed

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
2.5.1.1 microbatch-under-oil method, crystal structures of apoenzyme, ligand-bound enzyme, and inhibitor-bound structures Choristoneura fumiferana
2.5.1.10 microbatch-under-oil method, crystal structures of apoenzyme, ligand-bound enzyme, and inhibitor-bound structures Choristoneura fumiferana

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.5.1.1 dimethylallyl diphosphate + isopentenyl diphosphate Choristoneura fumiferana the enzyme catalyzes the condensation of two molecules of isopentenyl diphosphate with dimethylallyl diphosphate to generate the C15 product (2E,6E)-farnesyl diphosphate diphosphate + geranyl diphosphate
-
 ?
2.5.1.1 geranyl diphosphate + isopentenyl diphosphate Choristoneura fumiferana reaction of EC 2.5.1.10, the enzyme catalyzes the condensation of two molecules of isopentenyl diphosphate with dimethylallyl diphosphate to generate the C15 product (2E,6E)-farnesyl diphosphate diphosphate + (2E,6E)-farnesyl diphosphate
-
 ?
2.5.1.10 dimethylallyl diphosphate + isopentenyl diphosphate Choristoneura fumiferana the enzyme catalyzes the condensation of two molecules of isopentenyl diphosphate with dimethylallyl diphosphate to generate the C15 product (2E,6E)-farnesyl diphosphate, reaction of EC 2.5.1.1 diphosphate + geranyl diphosphate
-
 ?
2.5.1.10 geranyl diphosphate + isopentenyl diphosphate Choristoneura fumiferana the enzyme catalyzes the condensation of two molecules of isopentenyl diphosphate with dimethylallyl diphosphate to generate the C15 product (2E,6E)-farnesyl diphosphate diphosphate + (2E,6E)-farnesyl diphosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.5.1.1 Choristoneura fumiferana Q1XAB1
-
-
2.5.1.10 Choristoneura fumiferana Q1XAB1
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.5.1.1 dimethylallyl diphosphate + isopentenyl diphosphate the enzyme catalyzes the condensation of two molecules of isopentenyl diphosphate with dimethylallyl diphosphate to generate the C15 product (2E,6E)-farnesyl diphosphate Choristoneura fumiferana diphosphate + geranyl diphosphate
-
 ?
2.5.1.1 geranyl diphosphate + isopentenyl diphosphate reaction of EC 2.5.1.10, the enzyme catalyzes the condensation of two molecules of isopentenyl diphosphate with dimethylallyl diphosphate to generate the C15 product (2E,6E)-farnesyl diphosphate Choristoneura fumiferana diphosphate + (2E,6E)-farnesyl diphosphate
-
 ?
2.5.1.10 dimethylallyl diphosphate + isopentenyl diphosphate the enzyme catalyzes the condensation of two molecules of isopentenyl diphosphate with dimethylallyl diphosphate to generate the C15 product (2E,6E)-farnesyl diphosphate, reaction of EC 2.5.1.1 Choristoneura fumiferana diphosphate + geranyl diphosphate
-
 ?
2.5.1.10 geranyl diphosphate + isopentenyl diphosphate the enzyme catalyzes the condensation of two molecules of isopentenyl diphosphate with dimethylallyl diphosphate to generate the C15 product (2E,6E)-farnesyl diphosphate Choristoneura fumiferana diphosphate + (2E,6E)-farnesyl diphosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.5.1.1 FPPS2
-
 Choristoneura fumiferana
2.5.1.10 FPPS2
-
 Choristoneura fumiferana

General Information

EC Number General Information Comment Organism
2.5.1.1 metabolism the enzyme plays a key role in the biosynthesis of the morphogenetic and gonadotropic juvenile hormone Choristoneura fumiferana
2.5.1.10 metabolism the enzyme plays a key role in the biosynthesis of the morphogenetic and gonadotropic juvenile hormone Choristoneura fumiferana