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Literature summary extracted from

  • Galman, J.; Slabu, I.; Weise, N.; Iglesias, C.; Parmeggiani, F.; Lloyd, R.; Turner, N.
    Biocatalytic transamination with near-stoichiometric inexpensive amine donors mediated by bifunctional mono- and di-amine transaminases (2017), Green Chem., 19, 361-366 .
No PubMed abstract available

Application

EC Number Application Comment Organism
2.6.1.29 synthesis biocatalytic transamination with near-stoichiometric inexpensive amine donors mediated by bifunctional mono- and di-amine transaminases. Both monoamine and diamine transaminase activity is reported, allowing conversion of a wide range of target ketone substrates with just a small excess of amine donor. The diamine co-substrates (putrescine, cadaverine or spermidine) are bio-derived and the enzyme system results in very little waste, making it a greener strategy for the production of valuable amine fine chemicals and pharmaceuticals Pseudomonas aeruginosa
2.6.1.29 synthesis biocatalytic transamination with near-stoichiometric inexpensive amine donors mediated by bifunctional mono- and di-amine transaminases. Both monoamine and diamine transaminase activity is reported, allowing conversion of a wide range of target ketone substrates with just a small excess of amine donor. The diamine co-substrates (putrescine, cadaverine or spermidine) are bio-derived and the enzyme system results in very little waste, making it a greener strategy for the production of valuable amine fine chemicals and pharmaceuticals Pseudomonas putida
2.6.1.29 synthesis biocatalytic transamination with near-stoichiometric inexpensive amine donors mediated by bifunctional mono- and di-amine transaminases. Both monoamine and diamine transaminase activity is reported, allowing conversion of a wide range of target ketone substrates with just a small excess of amine donor. The diamine co-substrates (putrescine, cadaverine or spermidine) are bio-derived and the enzyme system results in very little waste, making it a greener strategy for the production of valuable amine fine chemicals and pharmaceuticals Pseudomonas chlororaphis subsp. aureofaciens
2.6.1.29 synthesis biocatalytic transamination with near-stoichiometric inexpensive amine donors mediated by bifunctional mono- and di-amine transaminases. Both monoamine and diamine transaminase activity is reported, allowing conversion of a wide range of target ketone substrates with just a small excess of amine donor. The diamine co-substrates (putrescine, cadaverine or spermidine) are bio-derived and the enzyme system results in very little waste, making it a greener strategy for the production of valuable amine fine chemicals and pharmaceuticals Pseudomonas fluorescens

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.6.1.29 gene spuC, recombinant overexpression in Escherichia coli strain BL21(DE3) Pseudomonas aeruginosa
2.6.1.29 gene spuC, recombinant overexpression in Escherichia coli strain BL21(DE3) Pseudomonas putida
2.6.1.29 gene spuC, recombinant overexpression in Escherichia coli strain BL21(DE3) Pseudomonas chlororaphis subsp. aureofaciens
2.6.1.29 gene spuC, recombinant overexpression in Escherichia coli strain BL21(DE3) Pseudomonas fluorescens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.6.1.29 an alpha,omega-diamine + 2-oxoglutarate Pseudomonas aeruginosa
-
 an omega-aminoaldehyde + L-glutamate
-
 ?
2.6.1.29 an alpha,omega-diamine + 2-oxoglutarate Pseudomonas putida
-
 an omega-aminoaldehyde + L-glutamate
-
 ?
2.6.1.29 an alpha,omega-diamine + 2-oxoglutarate Pseudomonas chlororaphis subsp. aureofaciens
-
 an omega-aminoaldehyde + L-glutamate
-
 ?
2.6.1.29 an alpha,omega-diamine + 2-oxoglutarate Pseudomonas fluorescens
-
 an omega-aminoaldehyde + L-glutamate
-
 ?
2.6.1.29 an alpha,omega-diamine + 2-oxoglutarate Pseudomonas aeruginosa ATCC 15692
-
 an omega-aminoaldehyde + L-glutamate
-
 ?
2.6.1.29 an alpha,omega-diamine + 2-oxoglutarate Pseudomonas fluorescens F113
-
 an omega-aminoaldehyde + L-glutamate
-
 ?
2.6.1.29 an alpha,omega-diamine + 2-oxoglutarate Pseudomonas aeruginosa 1C
-
 an omega-aminoaldehyde + L-glutamate
-
 ?
2.6.1.29 an alpha,omega-diamine + 2-oxoglutarate Pseudomonas aeruginosa PRS 101
-
 an omega-aminoaldehyde + L-glutamate
-
 ?
2.6.1.29 an alpha,omega-diamine + 2-oxoglutarate Pseudomonas aeruginosa DSM 22644
-
 an omega-aminoaldehyde + L-glutamate
-
 ?
2.6.1.29 an alpha,omega-diamine + 2-oxoglutarate Pseudomonas aeruginosa CIP 104116
-
 an omega-aminoaldehyde + L-glutamate
-
 ?
2.6.1.29 an alpha,omega-diamine + 2-oxoglutarate Pseudomonas aeruginosa LMG 12228
-
 an omega-aminoaldehyde + L-glutamate
-
 ?
2.6.1.29 an alpha,omega-diamine + 2-oxoglutarate Pseudomonas aeruginosa JCM 14847
-
 an omega-aminoaldehyde + L-glutamate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.6.1.29 Pseudomonas aeruginosa Q9I6J2
-
-
2.6.1.29 Pseudomonas aeruginosa 1C Q9I6J2
-
-
2.6.1.29 Pseudomonas aeruginosa ATCC 15692 Q9I6J2
-
-
2.6.1.29 Pseudomonas aeruginosa CIP 104116 Q9I6J2
-
-
2.6.1.29 Pseudomonas aeruginosa DSM 22644 Q9I6J2
-
-
2.6.1.29 Pseudomonas aeruginosa JCM 14847 Q9I6J2
-
-
2.6.1.29 Pseudomonas aeruginosa LMG 12228 Q9I6J2
-
-
2.6.1.29 Pseudomonas aeruginosa PRS 101 Q9I6J2
-
-
2.6.1.29 Pseudomonas chlororaphis subsp. aureofaciens A0A290U4C9
-
-
2.6.1.29 Pseudomonas fluorescens G8Q4R3
-
-
2.6.1.29 Pseudomonas fluorescens F113 G8Q4R3
-
-
2.6.1.29 Pseudomonas putida A0A4P8GNL5
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.6.1.29 an alpha,omega-diamine + 2-oxoglutarate
-
 Pseudomonas aeruginosa an omega-aminoaldehyde + L-glutamate
-
 ?
2.6.1.29 an alpha,omega-diamine + 2-oxoglutarate
-
 Pseudomonas putida an omega-aminoaldehyde + L-glutamate
-
 ?
2.6.1.29 an alpha,omega-diamine + 2-oxoglutarate
-
 Pseudomonas chlororaphis subsp. aureofaciens an omega-aminoaldehyde + L-glutamate
-
 ?
2.6.1.29 an alpha,omega-diamine + 2-oxoglutarate
-
 Pseudomonas fluorescens an omega-aminoaldehyde + L-glutamate
-
 ?
2.6.1.29 an alpha,omega-diamine + 2-oxoglutarate
-
 Pseudomonas aeruginosa ATCC 15692 an omega-aminoaldehyde + L-glutamate
-
 ?
2.6.1.29 an alpha,omega-diamine + 2-oxoglutarate
-
 Pseudomonas fluorescens F113 an omega-aminoaldehyde + L-glutamate
-
 ?
2.6.1.29 an alpha,omega-diamine + 2-oxoglutarate
-
 Pseudomonas aeruginosa 1C an omega-aminoaldehyde + L-glutamate
-
 ?
2.6.1.29 an alpha,omega-diamine + 2-oxoglutarate
-
 Pseudomonas aeruginosa PRS 101 an omega-aminoaldehyde + L-glutamate
-
 ?
2.6.1.29 an alpha,omega-diamine + 2-oxoglutarate
-
 Pseudomonas aeruginosa DSM 22644 an omega-aminoaldehyde + L-glutamate
-
 ?
2.6.1.29 an alpha,omega-diamine + 2-oxoglutarate
-
 Pseudomonas aeruginosa CIP 104116 an omega-aminoaldehyde + L-glutamate
-
 ?
2.6.1.29 an alpha,omega-diamine + 2-oxoglutarate
-
 Pseudomonas aeruginosa LMG 12228 an omega-aminoaldehyde + L-glutamate
-
 ?
2.6.1.29 an alpha,omega-diamine + 2-oxoglutarate
-
 Pseudomonas aeruginosa JCM 14847 an omega-aminoaldehyde + L-glutamate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.6.1.29 alpha,omega-diamine transaminase
-
 Pseudomonas aeruginosa
2.6.1.29 alpha,omega-diamine transaminase
-
 Pseudomonas putida
2.6.1.29 alpha,omega-diamine transaminase
-
 Pseudomonas chlororaphis subsp. aureofaciens
2.6.1.29 alpha,omega-diamine transaminase
-
 Pseudomonas fluorescens
2.6.1.29 alpha,omega-DTA
-
 Pseudomonas aeruginosa
2.6.1.29 alpha,omega-DTA
-
 Pseudomonas putida
2.6.1.29 bifunctional di-amine transaminase
-
 Pseudomonas aeruginosa
2.6.1.29 bifunctional mono- and di-amine transaminase
-
 Pseudomonas putida
2.6.1.29 bifunctional mono- and di-amine transaminase
-
 Pseudomonas chlororaphis subsp. aureofaciens
2.6.1.29 bifunctional mono- and di-amine transaminase
-
 Pseudomonas fluorescens
2.6.1.29 Pa-SpuC
-
 Pseudomonas aeruginosa
2.6.1.29 Pc-SpuC
-
 Pseudomonas chlororaphis subsp. aureofaciens
2.6.1.29 Pf-SpuC
-
 Pseudomonas fluorescens
2.6.1.29 Pp-SpuC
-
 Pseudomonas putida
2.6.1.29 SpuC
-
 Pseudomonas aeruginosa
2.6.1.29 SpuC
-
 Pseudomonas putida
2.6.1.29 SpuC
-
 Pseudomonas chlororaphis subsp. aureofaciens
2.6.1.29 SpuC
-
 Pseudomonas fluorescens

Cofactor

EC Number Cofactor Comment Organism Structure
2.6.1.29 pyridoxal 5'-phosphate
-
 Pseudomonas aeruginosa
2.6.1.29 pyridoxal 5'-phosphate
-
 Pseudomonas putida
2.6.1.29 pyridoxal 5'-phosphate
-
 Pseudomonas chlororaphis subsp. aureofaciens
2.6.1.29 pyridoxal 5'-phosphate
-
 Pseudomonas fluorescens