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Literature summary extracted from

  • Inamori, K.; Hara, Y.; Willer, T.; Anderson, M.E.; Zhu, Z.; Yoshida-Moriguchi, T.; Campbell, K.P.
    Xylosyl- and glucuronyltransferase functions of LARGE in alpha-dystroglycan modification are conserved in LARGE2 (2013), Glycobiology, 23, 295-302 .
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.4.1.B80
-
Mus musculus
2.4.2.B18
-
Mus musculus

Protein Variants

EC Number Protein Variants Comment Organism
2.4.1.B80 additional information expression of a secreted form that lack the transmembrane domain Mus musculus
2.4.2.B18 D242N/D244N glucuronyltransferase activity is comparable to that in wild type, whereas xylosyltransferase activity is undetectable Mus musculus
2.4.2.B18 D563N/D565N glucuronyltransferase activity is comparable to that in wild type, whereas xylosyltransferase activity is undetectable Mus musculus
2.4.2.B18 additional information expression of a secreted form that lack the transmembrane domain Mus musculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.4.1.B80 membrane
-
Mus musculus 16020
-
2.4.2.B18 membrane
-
Mus musculus 16020
-

Organism

EC Number Organism UniProt Comment Textmining
2.4.1.B80 Mus musculus Q5XPT3 isoform LARGE2
-
2.4.1.B80 Mus musculus Q9Z1M7 isoform LARGE1
-
2.4.2.B18 Mus musculus Q5XPT3 isoform LARGE2
-
2.4.2.B18 Mus musculus Q9Z1M7 isoform LARGE1
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.1.B80 additional information the enzyme is specific for the transfer of D-xylose and D-glucuronate. The enzyme is capable of synthesizing [3-alpha-D-xylosyl-(1->3)-beta-D-glucuronyl-1-] repeats Mus musculus ?
-
-
2.4.1.B80 UDP-alpha-D-glucuronate + 4-methylumbelliferyl alpha-D-xylosyl-(1->3)-beta-D-glucuronate
-
Mus musculus UDP + 4-methylumbelliferyl beta-D-glucuronosyl-(1->3)-alpha-D-xylosyl-(1->3)-beta-D-glucuronate
-
?
2.4.1.B80 UDP-alpha-D-glucuronate + 4-nitrophenyl alpha-D-xyloside
-
Mus musculus UDP + 4-nitrophenyl beta-D-glucuronyl-(1->3)-alpha-D-xyloside
-
?
2.4.1.B80 UDP-alpha-D-xylose + 4-methylumbelliferyl beta-D-glucuronate
-
Mus musculus UDP + 4-methylumbelliferyl alpha-D-xylosyl-(1->3)-beta-D-glucuronate
-
?
2.4.2.B18 additional information enzyme acts as a bifunctional glycosyltransferase, with both xylosyltransferase and glucuronyltransferase activities, producing repeating units of [3-alpha-D-xylosyl-(1->3)-beta-D-glucuronyl-1-] Mus musculus ?
-
-
2.4.2.B18 additional information enzyme is specific for transfer of D-xylose and D-glucuronate Mus musculus ?
-
-
2.4.2.B18 UDP-alpha-D-glucuronate + 4-nitrophenyl alpha-D-xyloside glucuronosyltransferase activity of the bifunctional enzyme Mus musculus UDP + 4-nitrophenyl beta-D-glucuronyl-(1->3)-alpha-D-xyloside
-
?
2.4.2.B18 UDP-alpha-D-xylose + 4-methylumbelliferyl beta-D-glucuronate xylosyltransferase activity of the bifunctional enzyme Mus musculus UDP + 4-methylumbelliferyl alpha-D-xylosyl-(1->3)-beta-D-glucuronate
-
?

Synonyms

EC Number Synonyms Comment Organism
2.4.1.B80 LARGE1
-
Mus musculus
2.4.2.B18 LARGE1
-
Mus musculus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.4.1.B80 5
-
xylosyltransferase activity, recombinant protein lacking the transmembrane domain Mus musculus
2.4.1.B80 5.5
-
glucuronyltransferase activity, recombinant protein lacking the transmembrane domain Mus musculus
2.4.1.B80 5.5 8 glucuronyltransferase activity, recombinant protein lacking the transmembrane domain Mus musculus
2.4.1.B80 5.5 9 xylosyltransferase activity, recombinant protein lacking the transmembrane domain Mus musculus
2.4.2.B18 5
-
xylosyltransferase activity, recombinant protein lacking the transmembrane domain Mus musculus
2.4.2.B18 5.5
-
glucuronyltransferase activity, recombinant protein lacking the transmembrane domain Mus musculus
2.4.2.B18 5.5 8 glucuronyltransferase activity, recombinant protein lacking the transmembrane domain Mus musculus
2.4.2.B18 5.5 9 xylosyltransferase activity, recombinant protein lacking the transmembrane domain Mus musculus