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Literature summary extracted from

  • Zhao, W.; Fan, A.; Tarcz, S.; Zhou, K.; Yin, W.B.; Liu, X.Q.; Li, S.M.
    Mutation on Gly115 and Tyr205 of the cyclic dipeptide C2-prenyltransferase FtmPT1 increases its catalytic activity toward hydroxynaphthalenes (2017), Appl. Microbiol. Biotechnol., 101, 1989-1998 .
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.5.1.106 expression in Escherichia coli Aspergillus fumigatus

Protein Variants

EC Number Protein Variants Comment Organism
2.5.1.106 G115A significantly increased acceptance of 1-naphthol and other hydroxynaphthalenes by the mutant enzyme Aspergillus fumigatus
2.5.1.106 G115A/Y205C significantly increased acceptance of 1-naphthol and other hydroxynaphthalenes by the mutant enzyme Aspergillus fumigatus
2.5.1.106 Y205C significantly increased acceptance of 1-naphthol and other hydroxynaphthalenes by the mutant enzyme Aspergillus fumigatus
2.5.1.106 Y205F significantly increased acceptance of 1-naphthol and other hydroxynaphthalenes by the mutant enzyme Aspergillus fumigatus
2.5.1.106 Y205I significantly increased acceptance of 1-naphthol and other hydroxynaphthalenes by the mutant enzyme Aspergillus fumigatus
2.5.1.106 Y205L significantly increased acceptance of 1-naphthol and other hydroxynaphthalenes by the mutant enzyme Aspergillus fumigatus
2.5.1.106 Y205M significantly increased acceptance of 1-naphthol and other hydroxynaphthalenes by the mutant enzyme Aspergillus fumigatus
2.5.1.106 Y205S significantly increased acceptance of 1-naphthol and other hydroxynaphthalenes by the mutant enzyme Aspergillus fumigatus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.5.1.106 brevianamide F + dimethylallyl diphosphate Aspergillus fumigatus
-
 diphosphate + tryprostatin B
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.5.1.106 Aspergillus fumigatus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.5.1.106
-
 Aspergillus fumigatus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.5.1.106 1,6-dihydroxynaphthalene + dimethylallyl diphosphate mutants Y205L, Y205M, Y205F, Y205C, Y205I, Y205S, and G115A_Y205C show higher catalytic activities than the non-mutated FtmPT1 Aspergillus fumigatus diphosphate + 4-(3-methylbut-2-en-1-yl)naphthalene-1,6-diol
-
 ?
2.5.1.106 1,7-dihydroxynaphthalene + dimethylallyl diphosphate mutants Y205L, Y205M, Y205F, Y205C, Y205I, Y205S, and G115A_Y205C show higher catalytic activities than the non-mutated FtmPT1 Aspergillus fumigatus diphosphate + 4-(3-methylbut-2-en-1-yl)naphthalene-1,7-diol
-
 ?
2.5.1.106 1-amino-7-hydroxynaphthalene + dimethylallyl diphosphate mutants Y205L, Y205M, Y205F, Y205C, Y205I, Y205S, and G115A_Y205C show higher catalytic activities than the non-mutated FtmPT1 Aspergillus fumigatus diphosphate + 8-amino-7-(3-methylbut-2-en-1-yl)naphthalen-2-ol
-
 ?
2.5.1.106 1-naphthol + dimethylallyl diphosphate mutants Y205L, Y205M, Y205F, Y205C, Y205I, Y205S, and G115A_Y205C show higher catalytic activities than the non-mutated FtmPT1 Aspergillus fumigatus diphosphate + 4-(3-methylbut-2-en-1-yl)naphthalen-1-ol
-
 ?
2.5.1.106 2,3-dihydroxynaphthalene + dimethylallyl diphosphate mutants Y205L, Y205M, Y205F, Y205C, Y205I, Y205S, and G115A_Y205C show higher catalytic activities than the non-mutated FtmPT1 Aspergillus fumigatus diphosphate + ?
-
 ?
2.5.1.106 2-naphthol + dimethylallyl diphosphate mutants Y205L, Y205M, Y205F, Y205C, Y205I, Y205S, and G115A_Y205C show higher catalytic activities than the non-mutated FtmPT1 Aspergillus fumigatus diphosphate + ?
-
 ?
2.5.1.106 brevianamide F + dimethylallyl diphosphate
-
 Aspergillus fumigatus diphosphate + tryprostatin B
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.5.1.106 cyclic dipeptide C2-prenyltransferase FtmPT1
-
 Aspergillus fumigatus

General Information

EC Number General Information Comment Organism
2.5.1.106 metabolism the enzyme is involved in the biosynthesis of a number of biologically active natural products including tryprostatins, spirotryprostatins, verruculogen, and fumitremorgins Aspergillus fumigatus