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Literature summary extracted from

  • Hawer, H.; Ütkür, K.; Arend, M.; Mayer, K.; Adrian, L.; Brinkmann, U.; Schaffrath, R.
    Importance of diphthamide modified EF2 for translational accuracy and competitive cell growth in yeast (2018), PLoS ONE, 13, e0205870 .
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.1.1.314 4 S-adenosyl-L-methionine + 2-[(3S)-3-carboxy-3-aminopropyl]-L-histidine-[translation elongation factor 2] Saccharomyces cerevisiae in eukaryotes, the modification of an invariant histidine (His-699 in yeast) residue in translation elongation factor 2 (EF2) with diphthamide involves a conserved pathway encoded by the DPH1-DPH7 gene network. Diphthamide is the target for diphtheria toxin and related lethal ADP ribosylases, which collectively kill cells by inactivating the essential translocase function of EF2 during mRNA translation and protein biosynthesis 4 S-adenosyl-L-homocysteine + diphthine methyl ester-[translation elongation factor 2]
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Organism

EC Number Organism UniProt Comment Textmining
2.1.1.314 Saccharomyces cerevisiae
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.314 4 S-adenosyl-L-methionine + 2-[(3S)-3-carboxy-3-aminopropyl]-L-histidine-[translation elongation factor 2]
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 Saccharomyces cerevisiae 4 S-adenosyl-L-homocysteine + diphthine methyl ester-[translation elongation factor 2]
-
 ?
2.1.1.314 4 S-adenosyl-L-methionine + 2-[(3S)-3-carboxy-3-aminopropyl]-L-histidine-[translation elongation factor 2] in eukaryotes, the modification of an invariant histidine (His-699 in yeast) residue in translation elongation factor 2 (EF2) with diphthamide involves a conserved pathway encoded by the DPH1-DPH7 gene network. Diphthamide is the target for diphtheria toxin and related lethal ADP ribosylases, which collectively kill cells by inactivating the essential translocase function of EF2 during mRNA translation and protein biosynthesis Saccharomyces cerevisiae 4 S-adenosyl-L-homocysteine + diphthine methyl ester-[translation elongation factor 2]
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 ?

Synonyms

EC Number Synonyms Comment Organism
2.1.1.314 Dph5
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 Saccharomyces cerevisiae

General Information

EC Number General Information Comment Organism
2.1.1.314 malfunction growth inhibition by higher-than-normal Dph5 levels produced from DPH5 overexpression Saccharomyces cerevisiae
2.1.1.314 physiological function the enzyme is involved in modification of an invariant histidine (His-699 in yeast) residue in translation elongation factor 2 (EF2) with diphthamide. Diphthamide modified EF2 is important for translational accuracy and competitive cell growth in yeast Saccharomyces cerevisiae