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Literature summary extracted from

  • Lee, T.V.; Sethi, M.K.; Leonardi, J.; Rana, N.A.; Buettner, F.F.; Haltiwanger, R.S.; Bakker, H.; Jafar-Nejad, H.
    Negative regulation of Notch signaling by xylose (2013), PLoS Genet., 9, e1003547 .
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.4.2.63 UDP-alpha-D-xylose + [Notch protein with EGF-like domain]-L-serine Drosophila melanogaster
-
 UDP + [Notch protein with EGF-like domain]-3-O-(beta-D-xylosyl)-L-serine
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.4.2.63 Drosophila melanogaster
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.2.63 UDP-alpha-D-xylose + [Notch protein with EGF-like domain]-L-serine
-
 Drosophila melanogaster UDP + [Notch protein with EGF-like domain]-3-O-(beta-D-xylosyl)-L-serine
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.4.2.63 CG9996
-
 Drosophila melanogaster
2.4.2.63 glucoside xylosyltransferase
-
 Drosophila melanogaster
2.4.2.63 Shams
-
 Drosophila melanogaster

General Information

EC Number General Information Comment Organism
2.4.2.63 malfunction enzyme mutations result in the loss of wing veins and head bristles. Notch surface expression in the pupal wing is increased upon loss of the enzyme Drosophila melanogaster
2.4.2.63 physiological function xylosylation of epidermal growth factor-like repeats 16-20 by the enzyme negatively regulates the surface expression of the Notch receptor Drosophila melanogaster