EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
2.3.1.74 | cytoplasm | - |
Rheum australe | 5737 | - |
2.3.1.74 | nucleus | - |
Rheum australe | 5634 | - |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.3.1.74 | 3 malonyl-CoA + 4-coumaroyl-CoA | Rheum australe | 100% activity | 4 CoA + naringenin chalcone + 3 CO2 | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.3.1.74 | Rheum australe | A0A096X8J8 | - |
- |
2.3.1.74 | Rheum australe | A0A0A0P7Q3 | - |
- |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.3.1.74 | (2RS)-methylmalonyl-CoA + n-hexanoyl-CoA | - |
Rheum australe | triketide lactone + 6-ethyl-4-hydroxy-3,5-dimethyl-2-pyrone | - |
? | |
2.3.1.74 | 3 malonyl-CoA + 4-coumaroyl-CoA | 100% activity | Rheum australe | 4 CoA + naringenin chalcone + 3 CO2 | - |
? | |
2.3.1.74 | 4-coumaroyl-CoA + (2RS)-methylmalonyl-CoA | - |
Rheum australe | 1-(4-hydroxyphenyl)pent-1-en-3-one | - |
? | |
2.3.1.74 | cinnamoyl diketide-NAC + (2RS)-methylmalonyl-CoA | - |
Rheum australe | methylated triketide styrylpyrone + ? | - |
? | |
2.3.1.74 | malonyl-CoA + 4-fluorocinnamoyl-CoA | - |
Rheum australe | fluorinated chalcone + alpha-pyrone + 2 CoA | - |
? | |
2.3.1.74 | malonyl-CoA + acetyl-CoA | isoform CHS1 exhibits 21.15% activity compared to 4-coumaryl-CoA | Rheum australe | ? | - |
? | |
2.3.1.74 | malonyl-CoA + acetyl-CoA | isoform CHS2 exhibits 138.11% activity compared to 4-coumaryl-CoA | Rheum australe | ? | - |
? | |
2.3.1.74 | malonyl-CoA + benzoyl-CoA | - |
Rheum australe | bis-noryangonin + 4-coumaroyl triacetic acid lactone + CoA + CO2 | - |
? | |
2.3.1.74 | malonyl-CoA + butyryl-CoA | isoform CHS1 exhibits 18.85% activity compared to 4-coumaryl-CoA | Rheum australe | ? | - |
? | |
2.3.1.74 | malonyl-CoA + butyryl-CoA | isoform CHS2 exhibits 45.38% activity compared to 4-coumaryl-CoA | Rheum australe | ? | - |
? | |
2.3.1.74 | malonyl-CoA + hexanoyl-CoA | isoform CHS1 exhibits 3.09% activity compared to 4-coumaryl-CoA | Rheum australe | ? | - |
? | |
2.3.1.74 | malonyl-CoA + hexanoyl-CoA | isoform CHS2 exhibits 2.36% activity compared to 4-coumaryl-CoA | Rheum australe | ? | - |
? | |
2.3.1.74 | malonyl-CoA + octanoyl-CoA | isoform CHS1 exhibits 22.04% activity compared to 4-coumaryl-CoA | Rheum australe | ? | - |
? | |
2.3.1.74 | malonyl-CoA + octanoyl-CoA | isoform CHS2 exhibits 72.39% activity compared to 4-coumaryl-CoA | Rheum australe | ? | - |
? | |
2.3.1.74 | methylmalonyl-CoA + benzoyl-CoA | - |
Rheum australe | triketide alpha-pyrone + tetraketide alpha-pyrone | - |
? | |
2.3.1.74 | n-hexanoyl-CoA + butyryl-CoA | - |
Rheum australe | phlorobutyrophenone + phlorocaprophenone | - |
? |
EC Number | Subunits | Comment | Organism |
---|---|---|---|
2.3.1.74 | homodimer | 2 * about 43230, calculated from amino acid sequence | Rheum australe |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
2.3.1.74 | Chs1 | isoform | Rheum australe |
2.3.1.74 | Chs2 | isoform | Rheum australe |
EC Number | Organism | Comment | pI Value Maximum | pI Value |
---|---|---|---|---|
2.3.1.74 | Rheum australe | calculated from amino acid sequence | - |
6 |
EC Number | General Information | Comment | Organism |
---|---|---|---|
2.3.1.74 | metabolism | the enzyme catalyzes the initial step of the phenylpropanoid pathway | Rheum australe |
EC Number | kcat/KM Value [1/mMs-1] | kcat/KM Value Maximum [1/mMs-1] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
2.3.1.74 | 10 | - |
hexanoyl-CoA | isoform CHS1, pH and temperature not specified in the publication | Rheum australe | |
2.3.1.74 | 30 | - |
octanoyl-CoA | isoform CHS1, pH and temperature not specified in the publication | Rheum australe | |
2.3.1.74 | 50 | - |
acetyl-CoA | isoform CHS1, pH and temperature not specified in the publication | Rheum australe | |
2.3.1.74 | 50 | - |
butyryl-CoA | isoform CHS1, pH and temperature not specified in the publication | Rheum australe | |
2.3.1.74 | 170 | - |
4-coumaroyl-CoA | isoform CHS2, pH and temperature not specified in the publication | Rheum australe | |
2.3.1.74 | 300 | - |
hexanoyl-CoA | isoform CHS2, pH and temperature not specified in the publication | Rheum australe | |
2.3.1.74 | 580 | - |
octanoyl-CoA | isoform CHS2, pH and temperature not specified in the publication | Rheum australe | |
2.3.1.74 | 787 | - |
4-coumaroyl-CoA | isoform CHS1, pH and temperature not specified in the publication | Rheum australe | |
2.3.1.74 | 990 | - |
butyryl-CoA | isoform CHS2, pH and temperature not specified in the publication | Rheum australe | |
2.3.1.74 | 1240 | - |
acetyl-CoA | isoform CHS2, pH and temperature not specified in the publication | Rheum australe |