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Literature summary extracted from

  • Li, X.; Yang, J.; Pu, Q.; Peng, X.; Xu, L.; Liu, S.
    Serine hydroxymethyltransferase controls blood-meal digestion in the midgut of Aedes aegypti mosquitoes (2019), Parasit. Vectors, 12, 460 .
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.1.2.1 expressed in Escherichia coli BL21(DE3) cells Aedes aegypti

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.1.2.1 5,10-methylenetetrahydrofolate + glycine + H2O Aedes aegypti
-
 tetrahydrofolate + L-serine
-
 r
2.1.2.1 5,10-methylenetetrahydrofolate + glycine + H2O Aedes aegypti NIH Rockefeller
-
 tetrahydrofolate + L-serine
-
 r
2.1.2.1 tetrahydrofolate + L-serine Aedes aegypti
-
 5,10-methylenetetrahydrofolate + glycine + H2O
-
 r
2.1.2.1 tetrahydrofolate + L-serine Aedes aegypti NIH Rockefeller
-
 5,10-methylenetetrahydrofolate + glycine + H2O
-
 r

Organism

EC Number Organism UniProt Comment Textmining
2.1.2.1 Aedes aegypti
-
-
-
2.1.2.1 Aedes aegypti NIH Rockefeller
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.1.2.1 Ni ion affinity column chromatography Aedes aegypti

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.1.2.1 midgut
-
 Aedes aegypti
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.2.1 5,10-methylenetetrahydrofolate + glycine + H2O
-
 Aedes aegypti tetrahydrofolate + L-serine
-
 r
2.1.2.1 5,10-methylenetetrahydrofolate + glycine + H2O
-
 Aedes aegypti NIH Rockefeller tetrahydrofolate + L-serine
-
 r
2.1.2.1 tetrahydrofolate + L-serine
-
 Aedes aegypti 5,10-methylenetetrahydrofolate + glycine + H2O
-
 r
2.1.2.1 tetrahydrofolate + L-serine
-
 Aedes aegypti NIH Rockefeller 5,10-methylenetetrahydrofolate + glycine + H2O
-
 r

Subunits

EC Number Subunits Comment Organism
2.1.2.1 ? x * 70000, SDS-PAGE Aedes aegypti

Synonyms

EC Number Synonyms Comment Organism
2.1.2.1 serine hydroxymethyltransferase
-
 Aedes aegypti
2.1.2.1 SHMT
-
 Aedes aegypti

Cofactor

EC Number Cofactor Comment Organism Structure
2.1.2.1 pyridoxal 5'-phosphate
-
 Aedes aegypti

General Information

EC Number General Information Comment Organism
2.1.2.1 malfunction digestion of blood is inhibited in enzyme RNAi-silenced female Aedes aegypti mosquitoes. Enzyme-depleted female mosquitoes lose their flight ability and die within 48 h of a blood meal Aedes aegypti