Literature summary extracted from

Baccile, J.A.; Spraker, J.E.; Le, H.H.; Brandenburger, E.; Gomez, C.; Bok, J.W.; Macheleidt, J.; Brakhage, A.A.; Hoffmeister, D.; Keller, N.P.; Schroeder, F.C.
Plant-like biosynthesis of isoquinoline alkaloids in Aspergillus fumigatus (2016), Nat. Chem. Biol., 12, 419-424 .

Organism

EC Number	Organism	UniProt	Comment	Textmining
2.1.1.140	Aspergillus fumigatus	-	-	-

Synonyms

EC Number	Synonyms	Comment	Organism
2.1.1.140	FspC	-	Aspergillus fumigatus

General Information

EC Number	General Information	Comment	Organism
2.1.1.140	physiological function	fumisoquin biosynthesis requires the N-methyltransferase FsqC and the FAD-dependent oxidase FsqB, which represent functional analogs of coclaurine N-methyltransferase and berberine bridge enzyme in plants. Deletion of the N-methyltransferase FsqC, phenol 2-monooxygenase FsqG, or FAD-dependent oxidase FsqB in a strain overexpressing FsqA leads to complete abolishment of isoquinoline alkaloid production and accumulation of a series of benzyl pyrroles, including fumipyrrole	Aspergillus fumigatus

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Release 2023.1 (January 2023)