Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Xu, X.; Mathieu, C.; Berthelet, J.; Duval, R.; Bui, L.C.; Busi, F.; Dupret, J.M.; Rodrigues-Lima, F.
    Human arylamine N-acetyltransferase 1 is inhibited by the dithiocarbamate pesticide thiram (2017), Mol. Pharmacol., 92, 358-365 .
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.3.1.5 expression in Escherichia coli Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.1.5 thiram irreversible inhibitor, modification of NAT1 catalytic cysteine residue Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.5 Homo sapiens P18440
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.5 HaCaT cell
-
Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.5 4-nitrophenyl acetate + 3,4-dichloroaniline
-
Homo sapiens 4-nitrophenol + N-acetyl-3,4-dichloroaniline
-
?
2.3.1.5 4-nitrophenyl acetate + 4-aminobenzoic acid
-
Homo sapiens 4-nitrophenol + N-acetyl-4-aminobenzoic acid
-
?

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.3.1.5 0.023
-
thiram 37°C, pH not specified in the publication Homo sapiens