Literature summary extracted from

Schaffrath, R.; Abdel-Fattah, W.; Klassen, R.; Stark, M.
The diphthamide modification pathway from Saccharomyces cerevisiae - revisited (2016), Mol. Microbiol., 94, 1213-1226 .

Natural Substrates/ Products (Substrates)

EC Number	Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
2.1.1.314	4 S-adenosyl-L-methionine + 2-[(3S)-3-carboxy-3-aminopropyl]-L-histidine-[translation elongation factor 2]	Saccharomyces cerevisiae	the enzyme is involved in the diphthamide modification pathway	4 S-adenosyl-L-homocysteine + diphthine methyl ester-[translation elongation factor 2]	-	?

Organism

EC Number	Organism	UniProt	Comment	Textmining
2.1.1.314	Saccharomyces cerevisiae	-	-	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
2.1.1.314	4 S-adenosyl-L-methionine + 2-[(3S)-3-carboxy-3-aminopropyl]-L-histidine-[translation elongation factor 2]	-	Saccharomyces cerevisiae	4 S-adenosyl-L-homocysteine + diphthine methyl ester-[translation elongation factor 2]	-	?
2.1.1.314	4 S-adenosyl-L-methionine + 2-[(3S)-3-carboxy-3-aminopropyl]-L-histidine-[translation elongation factor 2]	the enzyme is involved in the diphthamide modification pathway	Saccharomyces cerevisiae	4 S-adenosyl-L-homocysteine + diphthine methyl ester-[translation elongation factor 2]	-	?

Synonyms

EC Number	Synonyms	Comment	Organism
2.1.1.314	Dph5	-	Saccharomyces cerevisiae

General Information

EC Number	General Information	Comment	Organism
2.1.1.314	malfunction	DPH5 gene overexpression causes growth defects in several dph mutant backgrounds. Higher-than-normal levels of Dph5 can inhibit the function of EF2, particularly when the translation factor is incompletely modified	Saccharomyces cerevisiae
2.1.1.314	physiological function	the enzyme is involved in the diphthamide modification pathway	Saccharomyces cerevisiae

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)