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Literature summary extracted from

  • Barman-Aksoezen, J.; Halloy, F.; Iyer, P.S.; Schuemperli, D.; Minder, A.E.; Hall, J.; Minder, E.I.; Schneider-Yin, X.
    Delta-aminolevulinic acid synthase 2 expression in combination with iron as modifiers of disease severity in erythropoietic protoporphyria (2019), Mol. Genet. Metab., 128, 304-308 .
    View publication on PubMed

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.37 succinyl-CoA + glycine Homo sapiens
-
 5-aminolevulinate + CoA + CO2
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.37 Homo sapiens P22557
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.37 erythroid cell
-
 Homo sapiens
-
2.3.1.37 K-562 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.37 succinyl-CoA + glycine
-
 Homo sapiens 5-aminolevulinate + CoA + CO2
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.3.1.37 ALAS2
-
 Homo sapiens
2.3.1.37 aminolevulinic acid synthase 2
-
 Homo sapiens
2.3.1.37 delta-aminolevulinic acid synthase 2
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
2.3.1.37 pyridoxal 5'-phosphate
-
 Homo sapiens

Expression

EC Number Organism Comment Expression
2.3.1.37 Homo sapiens elevated mRNA and protein levels of isoform ALAS2 are observed among patients with erythropoietic protoporphyria. Iron deprivation increases the amount of isoform ALAS2 mRNA up