Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Stojanovski, B.M.; Hunter, G.A.; Na, I.; Uversky, V.N.; Jiang, R.H.Y.; Ferreira, G.C.
    5-Aminolevulinate synthase catalysis The catcher in heme biosynthesis (2019), Mol. Genet. Metab., 128, 178-189 .
    View publication on PubMedView publication on EuropePMC

Protein Variants

EC Number Protein Variants Comment Organism
2.3.1.37 K221V the mutant shows severely reduced catalytic efficiency towards succinyl-CoA compared to the wild type enzyme Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.37 succinyl-CoA + glycine Mus musculus
-
 5-aminolevulinate + CoA + CO2
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.37 Mus musculus P08680
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.37 erythroid cell
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.37 additional information no activity with L-alanine, L-serine or L-threonine Mus musculus ?
-
-
2.3.1.37 succinyl-CoA + glycine
-
 Mus musculus 5-aminolevulinate + CoA + CO2
-
 ?

Subunits

EC Number Subunits Comment Organism
2.3.1.37 homodimer
-
 Mus musculus

Synonyms

EC Number Synonyms Comment Organism
2.3.1.37 ALAS2
-
 Mus musculus

Cofactor

EC Number Cofactor Comment Organism Structure
2.3.1.37 pyridoxal 5'-phosphate
-
 Mus musculus