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Literature summary extracted from

  • Lee, K.; Hwang, O.J.; Reiter, R.J.; Back, K.
    Flavonoids inhibit both rice and sheep serotonin N-acetyltransferases and reduce melatonin levels in plants (2018), J. Pineal Res., 65, e12512 .
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.1.1.4 fisetin 0.1 mM, strong inhibition of N-acetylserotonin methyltransferase activity Oryza sativa Japonica Group
2.1.1.4 kaempferol 0.1 mM, strong inhibition of N-acetylserotonin methyltransferase activity Oryza sativa Japonica Group
2.1.1.4 luteolin 0.1 mM, strong inhibition of N-acetylserotonin methyltransferase activity Oryza sativa Japonica Group
2.1.1.4 additional information all of the flavonoids tested greatly inhibit the ASMT activity of COMT, and thus the melatonin biosynthetic activity, with the exception of catechin Oryza sativa Japonica Group
2.1.1.4 morin 0.1 mM, strong inhibition of N-acetylserotonin methyltransferase activity Oryza sativa Japonica Group
2.1.1.4 myricetin 0.1 mM, strong inhibition of N-acetylserotonin methyltransferase activity Oryza sativa Japonica Group
2.1.1.4 quercetin 0.1 mM, strong inhibition of N-acetylserotonin methyltransferase activity Oryza sativa Japonica Group
2.3.1.87 catechin poorest inhibitor tested, 0.1 mM, 1.6fold inhibition of isoform SNAT1 at 0.1 mM Oryza sativa
2.3.1.87 fisetin
-
 Oryza sativa
2.3.1.87 kaempferol
-
 Oryza sativa
2.3.1.87 luteolin
-
 Oryza sativa
2.3.1.87 morin 0.1 mM, 2fold inhibition Oryza sativa
2.3.1.87 morin 0.1 mM, 2fold inhibition Ovis aries
2.3.1.87 myricetin best inhibitor tested, 8fold inhibition of isoform SNAT1 at 0.1 mM Oryza sativa
2.3.1.87 myricetin 0.1 mM, 1.6fold inhibition Ovis aries
2.3.1.87 quercetin
-
 Oryza sativa
2.3.1.87 quercetin 0.1 mM, 1.2fold inhibition Ovis aries

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.4 Oryza sativa Japonica Group Q6ZD89 cf. EC 2.1.1.42
-
2.3.1.87 Oryza sativa
-
 cv. Dongjin
-
2.3.1.87 Ovis aries Q29495
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.1.1.4 leaf
-
 Oryza sativa Japonica Group
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.4 S-adenosyl-L-methionine + N-acetylserotonin
-
 Oryza sativa Japonica Group S-adenosyl-L-homocysteine + melatonin
-
 ?

General Information

EC Number General Information Comment Organism
2.1.1.4 physiological function rice leaves treated with flavonoids and then cadmium display lower melatonin levels than the flavonoid-untreated control Oryza sativa Japonica Group