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Literature summary extracted from

  • Massarweh, A.; Bosco, M.; Iatmanen-Harbi, S.; Tessier, C.; Auberger, N.; Busca, P.; Chantret, I.; Gravier-Pelletier, C.; Moore, S.E.
    Demonstration of an oligosaccharide-diphosphodolichol diphosphatase activity whose subcellular localization is different than those of dolichyl-phosphate-dependent enzymes of the dolichol cycle (2016), J. Lipid Res., 57, 1029-1042 .
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.6.1.44 citronellyl diphosphate
-
 Homo sapiens
3.6.1.44 farnesyl diphosphate
-
 Homo sapiens
3.6.1.44 geranyl diphosphate
-
 Homo sapiens
3.6.1.44 geranylgeranyl diphosphate
-
 Homo sapiens
3.6.1.44 GlcNAc-diphosphosolanesol
-
 Homo sapiens
3.6.1.44 GlcNAc2-diphosphosolanesol
-
 Homo sapiens
3.6.1.44 Hg2+
-
 Homo sapiens
3.6.1.44 isopentenyl diphosphate
-
 Homo sapiens
3.6.1.44 additional information not inhibited by NaF and EDTA Homo sapiens
3.6.1.44 solanesol
-
 Homo sapiens
3.6.1.44 solanesyl diphosphate
-
 Homo sapiens
3.6.1.44 solanesyl phosphate
-
 Homo sapiens
3.6.1.44 vanadate
-
 Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.6.1.44 Golgi apparatus
-
 Homo sapiens 5794
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.6.1.44 Co2+ dependent on, 1 mM used in assay conditions Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.6.1.44 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.6.1.44 Hep-G2 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.6.1.44 Glc2Man5GlcNAc2-diphosphodolichol + H2O
-
 Homo sapiens Glc2Man5GlcNAc2-phosphate + dolichyl phosphate
-
 ?
3.6.1.44 Glc2Man9GlcNAc2-diphosphodolichol + H2O
-
 Homo sapiens Glc2Man9GlcNAc2-phosphate + dolichyl phosphate
-
 ?
3.6.1.44 Glc3Man5GlcNAc2-diphosphodolichol + H2O
-
 Homo sapiens Glc3Man5GlcNAc2-phosphate + dolichyl phosphate
-
 ?
3.6.1.44 Glc3Man9GlcNAc2-diphosphodolichol + H2O
-
 Homo sapiens Glc3Man9GlcNAc2-phosphate + dolichyl phosphate
-
 ?
3.6.1.44 GlcMan5GlcNAc2-diphosphodolichol + H2O
-
 Homo sapiens GlcMan5GlcNAc2-phosphate + dolichyl phosphate
-
 ?
3.6.1.44 GlcMan9GlcNAc2-diphosphodolichol + H2O
-
 Homo sapiens GlcMan9GlcNAc2-phosphate + dolichyl phosphate
-
 ?
3.6.1.44 GlcNAc2-PP-solanesol + H2O
-
 Homo sapiens GlcNAc2-phosphate + solanesyl phosphate
-
 ?
3.6.1.44 Man5GlcNAc2-diphosphodolichol + H2O
-
 Homo sapiens Man5GlcNAc2-phosphate + dolichyl phosphate
-
 ?
3.6.1.44 Man7GlcNAc2-diphosphodolichol + H2O
-
 Homo sapiens Man7GlcNAc2 phosphate + dolichyl phosphate
-
 ?
3.6.1.44 Man9GlcNAc2-diphosphodolichol + H2O
-
 Homo sapiens Man9GlcNAc2-phosphate + dolichyl phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.6.1.44 DLO diphosphatase
-
 Homo sapiens
3.6.1.44 DLODP
-
 Homo sapiens
3.6.1.44 oligosaccharide-diphosphodolichol diphosphatase
-
 Homo sapiens

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
3.6.1.44 0.0005
-
 at pH 5.5 and 37°C Homo sapiens GlcNAc2-diphosphosolanesol
3.6.1.44 0.0012
-
 at pH 5.5 and 37°C Homo sapiens GlcNAc-diphosphosolanesol
3.6.1.44 0.0047
-
 at pH 5.5 and 37°C Homo sapiens solanesyl diphosphate
3.6.1.44 0.0078
-
 at pH 5.5 and 37°C Homo sapiens solanesyl phosphate
3.6.1.44 0.033
-
 at pH 5.5 and 37°C Homo sapiens solanesol