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Literature summary extracted from

  • Tang, X.L.; Chen, L.J.; Du, X.Y.; Zhang, B.; Liu, Z.Q.; Zheng, Y.G.
    Regulation of homoserine O-succinyltransferase for efficient production of L-methionine in engineered Escherichia coli (2020), J. Biotechnol., 309, 53-58 .
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.3.1.46 expressed in Escherichia coli strain DELTAIJA Escherichia coli

Protein Variants

EC Number Protein Variants Comment Organism
2.3.1.46 A28V the mutation leads to 2.94fold improved L-methionine productivity in Escherichia coli DELTAIJA strain Escherichia coli
2.3.1.46 I296S the mutation leads to improved L-methionine productivity in Escherichia coli DELTAIJA strain Escherichia coli
2.3.1.46 L63F the mutation leads to 2.91fold improved L-methionine productivity in Escherichia coli DELTAIJA strain Escherichia coli
2.3.1.46 L63F/A28V the mutations lead to 4.3fold improved L-methionine productivity in Escherichia coli DELTAIJA strain Escherichia coli
2.3.1.46 N267D the mutation leads to improved L-methionine productivity in Escherichia coli DELTAIJA strain Escherichia coli
2.3.1.46 P298L the mutation leads to 2.89fold improved L-methionine productivity in Escherichia coli DELTAIJA strain Escherichia coli
2.3.1.46 Q64E the mutation leads to improved L-methionine productivity in Escherichia coli DELTAIJA strain Escherichia coli
2.3.1.46 R27C the mutation leads to improved L-methionine productivity in Escherichia coli DELTAIJA strain Escherichia coli
2.3.1.46 S61T the mutation leads to improved L-methionine productivity in Escherichia coli DELTAIJA strain Escherichia coli

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.46 succinyl-CoA + L-homoserine Escherichia coli
-
 CoA + O-succinyl-L-homoserine
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.46 Escherichia coli P07623
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.46 succinyl-CoA + L-homoserine
-
 Escherichia coli CoA + O-succinyl-L-homoserine
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.3.1.46 MetA
-
 Escherichia coli

General Information

EC Number General Information Comment Organism
2.3.1.46 metabolism the enzyme catalyzes the initial step of L-methionine biosynthesis. Enzyme overexpression results in obviously improved L-methionine yield in Escherichia coli DELTAIJA strain Escherichia coli