Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Takeuchi, H.; Kantharia, J.; Sethi, M.; Bakker, H.; Haltiwanger, R.
    Site-specific O-glucosylation of the epidermal growth factor-like (EGF) repeats of Notch Efficiency of glycosylation is affected by proper folding and amino acid sequence of individual EGF repeats (2012), J. Biol. Chem., 287, 33934-33944 .
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.4.2.63 UDP-alpha-D-xylose + [Notch 2 protein with EGF-like domain]-L-serine Homo sapiens the di-serine motif within the O-glucose consensus sequence, CXSSPC, significantly enhances the enzyme activity UDP + [Notch 2 protein with EGF-like domain]-3-O-(beta-D-xylosyl)-L-serine
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.4.2.63 Homo sapiens
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.2.63 additional information EGF repeats without positively charged amino acids in or around the serine (EGF20, EGF33) and EGF repeats with positively charged amino acids (EGF16, EGF28) are no good substrates for enzyme activity. Neither EGF12 nor EGF27 is a good substrate for the enzyme activity Homo sapiens ?
-
-
2.4.2.63 UDP-alpha-D-xylose + [Notch 2 protein with EGF-like domain]-L-serine the di-serine motif within the O-glucose consensus sequence, CXSSPC, significantly enhances the enzyme activity Homo sapiens UDP + [Notch 2 protein with EGF-like domain]-3-O-(beta-D-xylosyl)-L-serine
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.4.2.63 Poxylt
-
 Homo sapiens
2.4.2.63 protein O-xylosyltransferase
-
 Homo sapiens
2.4.2.63 Rumi
-
 Homo sapiens