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Literature summary extracted from

  • Chen, B.; Long, Q.; Zhao, Y.; Wu, Y.; Ge, S.; Wang, P.; Yang, C.G.; Chi, Y.; Song, B.; Yang, S.
    Sulfone-based probes unraveled dihydrolipoamide S-succinyltransferase as an unprecedented target in phytopathogens (2019), J. Agric. Food Chem., 67, 6962-6969 .
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.3.1.61 expressed in Escherichia coli BL21 cells Xanthomonas oryzae pv. oryzae

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.1.61 2-(2,4-dichloro-3-[[(prop-2-yn-1-yl)oxy]methyl]phenyl)-5-(ethanesulfonyl)-1,3,4-oxadiazole
-
 Xanthomonas oryzae pv. oryzae
2.3.1.61 2-(2,4-dichloro-3-[[(prop-2-yn-1-yl)oxy]methyl]phenyl)-5-(methanesulfonyl)-1,3,4-oxadiazole
-
 Xanthomonas oryzae pv. oryzae
2.3.1.61 2-(4-fluoro-3-[[(prop-2-yn-1-yl)oxy]methyl]phenyl)-5-(methanesulfonyl)-1,3,4-oxadiazole
-
 Xanthomonas oryzae pv. oryzae
2.3.1.61 2-(4-fluorophenyl)-5-(methanesulfonyl)-1,3,4-oxadiazole
-
 Xanthomonas oryzae pv. oryzae
2.3.1.61 2-(ethanesulfonyl)-5-(4-fluoro-3-[[(prop-2-yn-1-yl)oxy]methyl]phenyl)-1,3,4-oxadiazole
-
 Xanthomonas oryzae pv. oryzae
2.3.1.61 2-(ethanesulfonyl)-5-(4-[[(prop-2-yn-1-yl)oxy]methyl]phenyl)-1,3,4-oxadiazole
-
 Xanthomonas oryzae pv. oryzae
2.3.1.61 2-(methanesulfonyl)-5-(4-[[(prop-2-yn-1-yl)oxy]methyl]phenyl)-1,3,4-oxadiazole
-
 Xanthomonas oryzae pv. oryzae
2.3.1.61 2-(methylsulfonyl)-5-(4-fluoro-3-((prop-2-yn-1-yloxy)methyl)-phenyl)-1,3,4-oxadiazole
-
 Xanthomonas citri
2.3.1.61 2-(methylsulfonyl)-5-(4-fluoro-3-((prop-2-yn-1-yloxy)methyl)-phenyl)-1,3,4-oxadiazole
-
 Xanthomonas oryzae pv. oryzae
2.3.1.61 additional information no activity with 5-(4-fluoro-3-((prop-2-yn-1-yloxy)methyl)phenyl)-1,3,4-oxadiazol-2-ol Xanthomonas citri
2.3.1.61 additional information no activity with 5-(4-fluoro-3-((prop-2-yn-1-yloxy)methyl)phenyl)-1,3,4-oxadiazol-2-ol Xanthomonas oryzae pv. oryzae

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.61 succinyl-CoA + enzyme N6-(dihydrolipoyl)lysine Xanthomonas citri
-
 CoA + enzyme N6-(S-succinyldihydrolipoyl)lysine
-
 ?
2.3.1.61 succinyl-CoA + enzyme N6-(dihydrolipoyl)lysine Xanthomonas oryzae pv. oryzae
-
 CoA + enzyme N6-(S-succinyldihydrolipoyl)lysine
-
 ?
2.3.1.61 succinyl-CoA + enzyme N6-(dihydrolipoyl)lysine Xanthomonas oryzae pv. oryzae PXO99A
-
 CoA + enzyme N6-(S-succinyldihydrolipoyl)lysine
-
 ?
2.3.1.61 succinyl-CoA + enzyme N6-(dihydrolipoyl)lysine Xanthomonas citri 29-1
-
 CoA + enzyme N6-(S-succinyldihydrolipoyl)lysine
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.61 Xanthomonas citri
-
-
-
2.3.1.61 Xanthomonas citri 29-1
-
-
-
2.3.1.61 Xanthomonas oryzae pv. oryzae
-
-
-
2.3.1.61 Xanthomonas oryzae pv. oryzae PXO99A
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.3.1.61 HisTrap column chromatography Xanthomonas oryzae pv. oryzae

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.61 succinyl-CoA + enzyme N6-(dihydrolipoyl)lysine
-
 Xanthomonas citri CoA + enzyme N6-(S-succinyldihydrolipoyl)lysine
-
 ?
2.3.1.61 succinyl-CoA + enzyme N6-(dihydrolipoyl)lysine
-
 Xanthomonas oryzae pv. oryzae CoA + enzyme N6-(S-succinyldihydrolipoyl)lysine
-
 ?
2.3.1.61 succinyl-CoA + enzyme N6-(dihydrolipoyl)lysine
-
 Xanthomonas oryzae pv. oryzae PXO99A CoA + enzyme N6-(S-succinyldihydrolipoyl)lysine
-
 ?
2.3.1.61 succinyl-CoA + enzyme N6-(dihydrolipoyl)lysine
-
 Xanthomonas citri 29-1 CoA + enzyme N6-(S-succinyldihydrolipoyl)lysine
-
 ?

Subunits

EC Number Subunits Comment Organism
2.3.1.61 ? x * 45000, SDS-PAGE Xanthomonas citri
2.3.1.61 ? x * 45000, SDS-PAGE Xanthomonas oryzae pv. oryzae
2.3.1.61 ? x * 42100, calculated from amino acid sequence Xanthomonas oryzae pv. oryzae

Synonyms

EC Number Synonyms Comment Organism
2.3.1.61 dihydrolipoamide S-succinyltransferase
-
 Xanthomonas citri
2.3.1.61 dihydrolipoamide S-succinyltransferase
-
 Xanthomonas oryzae pv. oryzae
2.3.1.61 DLST
-
 Xanthomonas citri
2.3.1.61 DLST
-
 Xanthomonas oryzae pv. oryzae
2.3.1.61 SucB
-
 Xanthomonas citri
2.3.1.61 SucB
-
 Xanthomonas oryzae pv. oryzae

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
2.3.1.61 0.00351
-
 at pH 7.2 and 28° Xanthomonas oryzae pv. oryzae 2-(4-fluorophenyl)-5-(methanesulfonyl)-1,3,4-oxadiazole
2.3.1.61 0.00358
-
 at pH 7.2 and 28° Xanthomonas oryzae pv. oryzae 2-(4-fluoro-3-[[(prop-2-yn-1-yl)oxy]methyl]phenyl)-5-(methanesulfonyl)-1,3,4-oxadiazole
2.3.1.61 0.00358
-
 at pH 7.2 and 28°C Xanthomonas oryzae pv. oryzae 2-(methylsulfonyl)-5-(4-fluoro-3-((prop-2-yn-1-yloxy)methyl)-phenyl)-1,3,4-oxadiazole
2.3.1.61 0.00399
-
 at pH 7.2 and 28° Xanthomonas oryzae pv. oryzae 2-(2,4-dichloro-3-[[(prop-2-yn-1-yl)oxy]methyl]phenyl)-5-(methanesulfonyl)-1,3,4-oxadiazole
2.3.1.61 0.00551
-
 at pH 7.2 and 28° Xanthomonas oryzae pv. oryzae 2-(methanesulfonyl)-5-(4-[[(prop-2-yn-1-yl)oxy]methyl]phenyl)-1,3,4-oxadiazole
2.3.1.61 0.0068
-
 at pH 7.2 and 28° Xanthomonas oryzae pv. oryzae 2-(2,4-dichloro-3-[[(prop-2-yn-1-yl)oxy]methyl]phenyl)-5-(ethanesulfonyl)-1,3,4-oxadiazole
2.3.1.61 0.00706
-
 at pH 7.2 and 28° Xanthomonas oryzae pv. oryzae 2-(ethanesulfonyl)-5-(4-fluoro-3-[[(prop-2-yn-1-yl)oxy]methyl]phenyl)-1,3,4-oxadiazole
2.3.1.61 0.00795
-
 at pH 7.2 and 28° Xanthomonas oryzae pv. oryzae 2-(ethanesulfonyl)-5-(4-fluoro-3-[[(prop-2-yn-1-yl)oxy]methyl]phenyl)-1,3,4-oxadiazole
2.3.1.61 0.00859
-
 at pH 7.2 and 28° Xanthomonas oryzae pv. oryzae 2-(4-fluorophenyl)-5-(methanesulfonyl)-1,3,4-oxadiazole
2.3.1.61 0.01263
-
 at pH 7.2 and 28° Xanthomonas oryzae pv. oryzae 2-(ethanesulfonyl)-5-(4-[[(prop-2-yn-1-yl)oxy]methyl]phenyl)-1,3,4-oxadiazole
2.3.1.61 0.01394
-
 at pH 7.2 and 28° Xanthomonas oryzae pv. oryzae 2-(ethanesulfonyl)-5-(4-[[(prop-2-yn-1-yl)oxy]methyl]phenyl)-1,3,4-oxadiazole
2.3.1.61 0.0156
-
 at pH 7.2 and 28° Xanthomonas oryzae pv. oryzae 2-(methanesulfonyl)-5-(4-[[(prop-2-yn-1-yl)oxy]methyl]phenyl)-1,3,4-oxadiazole
2.3.1.61 0.01753
-
 at pH 7.2 and 28° Xanthomonas oryzae pv. oryzae 2-(4-fluoro-3-[[(prop-2-yn-1-yl)oxy]methyl]phenyl)-5-(methanesulfonyl)-1,3,4-oxadiazole
2.3.1.61 0.01753
-
 at pH 7.2 and 28°C Xanthomonas citri 2-(methylsulfonyl)-5-(4-fluoro-3-((prop-2-yn-1-yloxy)methyl)-phenyl)-1,3,4-oxadiazole