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Literature summary extracted from

  • Tsuda-Sakurai, K.; Kimura, M.; Miura, M.
    Diphthamide modification of eEF2 is required for gut tumor-like hyperplasia induced by oncogenic Ras (2020), Genes Cells, 25, 76-85 .
    View publication on PubMed

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.1.1.314 4 S-adenosyl-L-methionine + 2-[(3S)-3-carboxy-3-aminopropyl]-L-histidine-[translation elongation factor 2] Drosophila sp. (in: flies) post-translational modification of eukaryotic elongation factor 2 (eEF2) 4 S-adenosyl-L-homocysteine + diphthine methyl ester-[translation elongation factor 2]
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 ?

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.314 Drosophila sp. (in: flies)
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.314 4 S-adenosyl-L-methionine + 2-[(3S)-3-carboxy-3-aminopropyl]-L-histidine-[translation elongation factor 2]
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 Drosophila sp. (in: flies) 4 S-adenosyl-L-homocysteine + diphthine methyl ester-[translation elongation factor 2]
-
 ?
2.1.1.314 4 S-adenosyl-L-methionine + 2-[(3S)-3-carboxy-3-aminopropyl]-L-histidine-[translation elongation factor 2] post-translational modification of eukaryotic elongation factor 2 (eEF2) Drosophila sp. (in: flies) 4 S-adenosyl-L-homocysteine + diphthine methyl ester-[translation elongation factor 2]
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 ?

Synonyms

EC Number Synonyms Comment Organism
2.1.1.314 Dph5
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 Drosophila sp. (in: flies)

General Information

EC Number General Information Comment Organism
2.1.1.314 physiological function Dph5 is required for gross translation activation and high dMyc protein level in RasV12 tumor-like hyperplasia. Dph5 is involved in the regulation of ribosome biogenesis genes. Diphthamidation is required for translation activation partly through the regulation of ribosome biogenesis in Ras-induced tumor-like hyperplasia model in Drosophila gut Drosophila sp. (in: flies)