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Literature summary extracted from

  • Delgado-Carmona, J.D.; Ramirez-Quijas, M.D.; Vega-Gonzalez, A.; Lopez-Romero, E.; Cuellar-Cruz, M.
    Changes in GDPase/UDPase enzymatic activity in response to oxidative stress in four Candida species (2015), Folia Microbiol. (Praha), 60, 343-350 .
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.6.1.6 H2O2 in the presence of H2O2, UDPase activity is lower than that of GDPase. GDPase activity significantly decreases at high concentrations. Inverse relationship between the decline in UDPase activity and the increase in the concentration of H2O2 Candida albicans
3.6.1.6 H2O2 in the presence of H2O2, UDPase activity is lower than that of GDPase. GDPase activity significantly decreases at high concentrations. Inverse relationship between the decline in UDPase activity and the increase in the concentration of H2O2 Candida parapsilosis
3.6.1.6 H2O2 in the presence of H2O2, UDPase activity is lower than that of GDPase. GDPase activity significantly decreases at high concentrations. Inverse relationship between the decline in UDPase activity and the increase in the concentration of H2O2 Nakaseomyces glabratus
3.6.1.6 H2O2 in the presence of H2O2, UDPase activity is lower than that of GDPase. GDPase activity significantly decreases at high concentrations. Inverse relationship between the decline in UDPase activity and the increase in the concentration of H2O2 Pichia kudriavzevii
3.6.1.6 menadione
-
 Candida albicans
3.6.1.6 menadione UDPase activity increases at lower concentrations of the oxidant and decreases at higher concentrations Candida parapsilosis
3.6.1.6 menadione UDPase activity increases at lower concentrations of the oxidant and decreases at higher concentrations Nakaseomyces glabratus
3.6.1.6 menadione
-
 Pichia kudriavzevii
3.6.1.6 additional information GDPase and UDPase activities are generally affected by H2O2 and the superoxide ion generated by menadione Candida albicans
3.6.1.6 additional information GDPase and UDPase activities are generally affected by H2O2 and the superoxide ion generated by menadione Candida parapsilosis
3.6.1.6 additional information GDPase and UDPase activities are generally affected by H2O2 and the superoxide ion generated by menadione Nakaseomyces glabratus
3.6.1.6 additional information GDPase and UDPase activities are generally affected by H2O2 and the superoxide ion generated by menadione Pichia kudriavzevii
3.6.1.6 superoxide GDPase activity significantly decreases at high concentrations Candida albicans
3.6.1.6 superoxide GDPase activity significantly decreases at high concentrations Candida parapsilosis
3.6.1.6 superoxide GDPase activity significantly decreases at high concentrations Nakaseomyces glabratus
3.6.1.6 superoxide GDPase activity significantly decreases at high concentrations Pichia kudriavzevii

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.6.1.6 microsome
-
 Candida albicans
-
-
3.6.1.6 microsome
-
 Nakaseomyces glabratus
-
-
3.6.1.6 microsome
-
 Pichia kudriavzevii
-
-
3.6.1.6 microsome
-
 Candida parapsilosis
-
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.6.1.6 Ca2+ required Candida albicans
3.6.1.6 Ca2+ required Candida parapsilosis
3.6.1.6 Ca2+ required Nakaseomyces glabratus
3.6.1.6 Ca2+ required Pichia kudriavzevii

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.6.1.6 GDP + H2O Candida albicans
-
 GMP + phosphate
-
 ?
3.6.1.6 GDP + H2O Nakaseomyces glabratus
-
 GMP + phosphate
-
 ?
3.6.1.6 GDP + H2O Pichia kudriavzevii
-
 GMP + phosphate
-
 ?
3.6.1.6 GDP + H2O Candida parapsilosis
-
 GMP + phosphate
-
 ?
3.6.1.6 UDP + H2O Candida albicans
-
 UMP + phosphate
-
 ?
3.6.1.6 UDP + H2O Nakaseomyces glabratus
-
 UMP + phosphate
-
 ?
3.6.1.6 UDP + H2O Pichia kudriavzevii
-
 UMP + phosphate
-
 ?
3.6.1.6 UDP + H2O Candida parapsilosis
-
 UMP + phosphate
-
 ?
3.6.1.42 GDP + H2O Candida parapsilosis
-
 GMP + phosphate
-
 ?
3.6.1.42 GDP + H2O Candida albicans
-
 GMP + phosphate
-
 ?
3.6.1.42 GDP + H2O Nakaseomyces glabratus
-
 GMP + phosphate
-
 ?
3.6.1.42 GDP + H2O Pichia kudriavzevii
-
 GMP + phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.6.1.6 Candida albicans
-
 clinical isolate from Mexico
-
3.6.1.6 Candida parapsilosis
-
 clinical isolate from Mexico
-
3.6.1.6 Nakaseomyces glabratus
-
 clinical isolate from Mexico
-
3.6.1.6 Pichia kudriavzevii
-
 clinical isolate from Mexico
-
3.6.1.42 Candida albicans
-
-
-
3.6.1.42 Candida parapsilosis
-
-
-
3.6.1.42 Nakaseomyces glabratus
-
-
-
3.6.1.42 Pichia kudriavzevii
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.6.1.6 GDP + H2O
-
 Candida albicans GMP + phosphate
-
 ?
3.6.1.6 GDP + H2O
-
 Nakaseomyces glabratus GMP + phosphate
-
 ?
3.6.1.6 GDP + H2O
-
 Pichia kudriavzevii GMP + phosphate
-
 ?
3.6.1.6 GDP + H2O
-
 Candida parapsilosis GMP + phosphate
-
 ?
3.6.1.6 UDP + H2O
-
 Candida albicans UMP + phosphate
-
 ?
3.6.1.6 UDP + H2O
-
 Nakaseomyces glabratus UMP + phosphate
-
 ?
3.6.1.6 UDP + H2O
-
 Pichia kudriavzevii UMP + phosphate
-
 ?
3.6.1.6 UDP + H2O
-
 Candida parapsilosis UMP + phosphate
-
 ?
3.6.1.42 GDP + H2O
-
 Candida parapsilosis GMP + phosphate
-
 ?
3.6.1.42 GDP + H2O
-
 Candida albicans GMP + phosphate
-
 ?
3.6.1.42 GDP + H2O
-
 Nakaseomyces glabratus GMP + phosphate
-
 ?
3.6.1.42 GDP + H2O
-
 Pichia kudriavzevii GMP + phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.6.1.6 GDPase
-
 Candida albicans
3.6.1.6 GDPase
-
 Nakaseomyces glabratus
3.6.1.6 GDPase
-
 Pichia kudriavzevii
3.6.1.6 GDPase
-
 Candida parapsilosis
3.6.1.6 GDPase/UDPase
-
 Candida albicans
3.6.1.6 GDPase/UDPase
-
 Nakaseomyces glabratus
3.6.1.6 GDPase/UDPase
-
 Pichia kudriavzevii
3.6.1.6 GDPase/UDPase
-
 Candida parapsilosis
3.6.1.6 NDPase
-
 Candida albicans
3.6.1.6 NDPase
-
 Nakaseomyces glabratus
3.6.1.6 NDPase
-
 Pichia kudriavzevii
3.6.1.6 NDPase
-
 Candida parapsilosis
3.6.1.6 UDPase
-
 Candida albicans
3.6.1.6 UDPase
-
 Nakaseomyces glabratus
3.6.1.6 UDPase
-
 Pichia kudriavzevii
3.6.1.6 UDPase
-
 Candida parapsilosis
3.6.1.42 GDPase
-
 Candida parapsilosis
3.6.1.42 GDPase
-
 Candida albicans
3.6.1.42 GDPase
-
 Nakaseomyces glabratus
3.6.1.42 GDPase
-
 Pichia kudriavzevii

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.6.1.6 37
-
 assay at Candida albicans
3.6.1.6 37
-
 assay at Candida parapsilosis
3.6.1.6 37
-
 assay at Nakaseomyces glabratus
3.6.1.6 37
-
 assay at Pichia kudriavzevii

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.6.1.6 7.5
-
 assay at Candida albicans
3.6.1.6 7.5
-
 assay at Nakaseomyces glabratus
3.6.1.6 7.5
-
 assay at Pichia kudriavzevii
3.6.1.6 7.5
-
 assay at Candida parapsilosis

Expression

EC Number Organism Comment Expression
3.6.1.42 Candida parapsilosis the enzyme activity significantly decreases at high concentrations of menadione, H2O2 and O2- down
3.6.1.42 Candida albicans the enzyme activity significantly decreases at high concentrations of menadione, H2O2 and O2- down
3.6.1.42 Nakaseomyces glabratus the enzyme activity significantly decreases at high concentrations of menadione, H2O2 and O2- down
3.6.1.42 Pichia kudriavzevii the enzyme activity significantly decreases at high concentrations of menadione, H2O2 and O2- down

General Information

EC Number General Information Comment Organism
3.6.1.6 metabolism the organism shows a basic mechanism to cope with oxidative stress, suggesting that the pathogen might activate mechanisms for UDPase synthesis at lower concentrations of superoxide. Differential response to oxidative stress by different Candida species, overview Candida albicans
3.6.1.6 metabolism the organism shows a basic mechanism to cope with oxidative stress, suggesting that the pathogen might activate mechanisms for UDPase synthesis at lower concentrations of superoxide. Differential response to oxidative stress by different Candida species, overview Nakaseomyces glabratus
3.6.1.6 metabolism the organism shows a basic mechanism to cope with oxidative stress, suggesting that the pathogen might activate mechanisms for UDPase synthesis at lower concentrations of superoxide. Differential response to oxidative stress by different Candida species, overview Pichia kudriavzevii
3.6.1.6 metabolism the organism shows a basic mechanism to cope with oxidative stress, suggesting that the pathogen might activate mechanisms for UDPase synthesis at lower concentrations of superoxide. Differential response to oxidative stress by different Candida species, overview Candida parapsilosis
3.6.1.6 physiological function the terminal processing of proteins and lipids occurs in the Golgi apparatus and involves the transport of sugar nucleotides into the Golgi lumen by specific carriers and the accumulation of nucleoside diphosphates (NDPs) as a result of oligosaccharide-protein glycosyltransferase activity. NDPs are converted into the corresponding nucleoside monophosphates (NMPs) by nucleoside diphosphatases (NDPases), thus relieving inhibition of sugar transferases. NMPs are then exchanged for equimolecular amounts of cytosolic sugar nucleotides by antiport transport systems. NDPases, commonly GDPase and UDPase, thus play a critical role in glycoprotein maturation and may influence fungal pathogenesis, morphogenesis, and cell wall properties Candida albicans
3.6.1.6 physiological function the terminal processing of proteins and lipids occurs in the Golgi apparatus and involves the transport of sugar nucleotides into the Golgi lumen by specific carriers and the accumulation of nucleoside diphosphates (NDPs) as a result of oligosaccharide-protein glycosyltransferase activity. NDPs are converted into the corresponding nucleoside monophosphates (NMPs) by nucleoside diphosphatases (NDPases), thus relieving inhibition of sugar transferases. NMPs are then exchanged for equimolecular amounts of cytosolic sugar nucleotides by antiport transport systems. NDPases, commonly GDPase and UDPase, thus play a critical role in glycoprotein maturation and may influence fungal pathogenesis, morphogenesis, and cell wall properties Nakaseomyces glabratus
3.6.1.6 physiological function the terminal processing of proteins and lipids occurs in the Golgi apparatus and involves the transport of sugar nucleotides into the Golgi lumen by specific carriers and the accumulation of nucleoside diphosphates (NDPs) as a result of oligosaccharide-protein glycosyltransferase activity. NDPs are converted into the corresponding nucleoside monophosphates (NMPs) by nucleoside diphosphatases (NDPases), thus relieving inhibition of sugar transferases. NMPs are then exchanged for equimolecular amounts of cytosolic sugar nucleotides by antiport transport systems. NDPases, commonly GDPase and UDPase, thus play a critical role in glycoprotein maturation and may influence fungal pathogenesis, morphogenesis, and cell wall properties Pichia kudriavzevii
3.6.1.6 physiological function the terminal processing of proteins and lipids occurs in the Golgi apparatus and involves the transport of sugar nucleotides into the Golgi lumen by specific carriers and the accumulation of nucleoside diphosphates (NDPs) as a result of oligosaccharide-protein glycosyltransferase activity. NDPs are converted into the corresponding nucleoside monophosphates (NMPs) by nucleoside diphosphatases (NDPases), thus relieving inhibition of sugar transferases. NMPs are then exchanged for equimolecular amounts of cytosolic sugar nucleotides by antiport transport systems. NDPases, commonly GDPase and UDPase, thus play a critical role in glycoprotein maturation and may influence fungal pathogenesis, morphogenesis, and cell wall properties Candida parapsilosis