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Literature summary extracted from

  • Paiva, P.; Sousa, S.; Fernandes, P.; Joao Ramos, M.
    Human Fatty Acid Synthase A Computational study of the transfer of the acyl moieties from mat to the ACP domain (2019), ChemCatChem, 11, 3853-3864 .
No PubMed abstract available

Protein Variants

EC Number Protein Variants Comment Organism
2.3.1.39 R606A the mutation reduces the malonyl transacylase activity and, on the other hand, renders better transferase activity concerning the acetyl moiety Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.39 acetyl-CoA + an [acyl-carrier protein] Homo sapiens
-
 CoA + an acetyl-[acyl-carrier protein]
-
 ?
2.3.1.39 malonyl-CoA + an [acyl-carrier protein] Homo sapiens
-
 CoA + a malonyl-[acyl-carrier protein]
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.39 Homo sapiens
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.39 acetyl-CoA + an [acyl-carrier protein]
-
 Homo sapiens CoA + an acetyl-[acyl-carrier protein]
-
 ?
2.3.1.39 malonyl-CoA + an [acyl-carrier protein]
-
 Homo sapiens CoA + a malonyl-[acyl-carrier protein]
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.3.1.39 FAS
-
 Homo sapiens
2.3.1.39 fatty acid synthase
-
 Homo sapiens
2.3.1.39 MAT malonyl-acetyl transferase domain of fatty acid synthase Homo sapiens