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Literature summary extracted from

  • Tomoike, F.; Tsunetou, A.; Kim, K.; Nakagawa, N.; Kuramitsu, S.; Masui, R.
    A putative adenosine kinase family protein possesses adenosine diphosphatase activity (2016), Biosci. Biotechnol. Biochem., 80, 2138-2143 .
    View publication on PubMed

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
3.6.1.6 crystal structure comparison of homologous structures of TTHA1091 protein (PDB ID 1VGG) and PAE2307 protein (PDB ID 1WVQ, from Pyrobaculum aerophilum strain ATCC 51768), overview Thermus thermophilus
3.6.1.6 crystal structure comparison of homologous structures of TTHA1091 protein (PDB ID 1VGG, from Thermus thermophilus strain HB8) and PAE2307 protein (PDB ID 1WVQ), overview Pyrobaculum aerophilum

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.6.1.6 Ca2+ about 90% inhibition at 10 mM Thermus thermophilus
3.6.1.6 Mg2+ complete inhibition at 10 mM Thermus thermophilus
3.6.1.6 Mn2+ complete inhibition at 10 mM Thermus thermophilus
3.6.1.6 additional information the ADPase activity is inhibited by divalent cations Thermus thermophilus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.6.1.6 ADP + H2O Pyrobaculum aerophilum
-
 AMP + phosphate
-
 ?
3.6.1.6 ADP + H2O Thermus thermophilus
-
 AMP + phosphate
-
 ?
3.6.1.6 ADP + H2O Pyrobaculum aerophilum DSM 7523
-
 AMP + phosphate
-
 ?
3.6.1.6 ADP + H2O Pyrobaculum aerophilum IM2
-
 AMP + phosphate
-
 ?
3.6.1.6 ADP + H2O Thermus thermophilus DSM 579
-
 AMP + phosphate
-
 ?
3.6.1.6 ADP + H2O Pyrobaculum aerophilum NBRC 100827
-
 AMP + phosphate
-
 ?
3.6.1.6 ADP + H2O Pyrobaculum aerophilum ATCC 51768
-
 AMP + phosphate
-
 ?
3.6.1.6 ADP + H2O Pyrobaculum aerophilum JCM 9630
-
 AMP + phosphate
-
 ?
3.6.1.6 ADP + H2O Thermus thermophilus ATCC 27634
-
 AMP + phosphate
-
 ?
3.6.1.6 CDP + H2O Pyrobaculum aerophilum
-
 CMP + phosphate
-
 ?
3.6.1.6 CDP + H2O Thermus thermophilus
-
 CMP + phosphate
-
 ?
3.6.1.6 CDP + H2O Pyrobaculum aerophilum DSM 7523
-
 CMP + phosphate
-
 ?
3.6.1.6 CDP + H2O Pyrobaculum aerophilum IM2
-
 CMP + phosphate
-
 ?
3.6.1.6 CDP + H2O Pyrobaculum aerophilum NBRC 100827
-
 CMP + phosphate
-
 ?
3.6.1.6 CDP + H2O Pyrobaculum aerophilum ATCC 51768
-
 CMP + phosphate
-
 ?
3.6.1.6 CDP + H2O Pyrobaculum aerophilum JCM 9630
-
 CMP + phosphate
-
 ?
3.6.1.6 additional information Thermus thermophilus the TTHA1091 protein does not possess ADK activity but instead possesses adenosine diphosphatase (ADPase) activity ?
-
-
3.6.1.6 additional information Thermus thermophilus DSM 579 the TTHA1091 protein does not possess ADK activity but instead possesses adenosine diphosphatase (ADPase) activity ?
-
-
3.6.1.6 additional information Thermus thermophilus ATCC 27634 the TTHA1091 protein does not possess ADK activity but instead possesses adenosine diphosphatase (ADPase) activity ?
-
-

Organism

EC Number Organism UniProt Comment Textmining
3.6.1.6 Pyrobaculum aerophilum Q8ZVF7
-
-
3.6.1.6 Pyrobaculum aerophilum ATCC 51768 Q8ZVF7
-
-
3.6.1.6 Pyrobaculum aerophilum DSM 7523 Q8ZVF7
-
-
3.6.1.6 Pyrobaculum aerophilum IM2 Q8ZVF7
-
-
3.6.1.6 Pyrobaculum aerophilum JCM 9630 Q8ZVF7
-
-
3.6.1.6 Pyrobaculum aerophilum NBRC 100827 Q8ZVF7
-
-
3.6.1.6 Thermus thermophilus Q5SJC3
-
-
3.6.1.6 Thermus thermophilus ATCC 27634 Q5SJC3
-
-
3.6.1.6 Thermus thermophilus DSM 579 Q5SJC3
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.6.1.6 ADP + H2O
-
 Pyrobaculum aerophilum AMP + phosphate
-
 ?
3.6.1.6 ADP + H2O
-
 Thermus thermophilus AMP + phosphate
-
 ?
3.6.1.6 ADP + H2O best substrate Thermus thermophilus AMP + phosphate
-
 ?
3.6.1.6 ADP + H2O
-
 Pyrobaculum aerophilum DSM 7523 AMP + phosphate
-
 ?
3.6.1.6 ADP + H2O
-
 Pyrobaculum aerophilum IM2 AMP + phosphate
-
 ?
3.6.1.6 ADP + H2O
-
 Thermus thermophilus DSM 579 AMP + phosphate
-
 ?
3.6.1.6 ADP + H2O best substrate Thermus thermophilus DSM 579 AMP + phosphate
-
 ?
3.6.1.6 ADP + H2O
-
 Pyrobaculum aerophilum NBRC 100827 AMP + phosphate
-
 ?
3.6.1.6 ADP + H2O
-
 Pyrobaculum aerophilum ATCC 51768 AMP + phosphate
-
 ?
3.6.1.6 ADP + H2O
-
 Pyrobaculum aerophilum JCM 9630 AMP + phosphate
-
 ?
3.6.1.6 ADP + H2O
-
 Thermus thermophilus ATCC 27634 AMP + phosphate
-
 ?
3.6.1.6 ADP + H2O best substrate Thermus thermophilus ATCC 27634 AMP + phosphate
-
 ?
3.6.1.6 CDP + H2O
-
 Pyrobaculum aerophilum CMP + phosphate
-
 ?
3.6.1.6 CDP + H2O
-
 Thermus thermophilus CMP + phosphate
-
 ?
3.6.1.6 CDP + H2O higher activity Thermus thermophilus CMP + phosphate
-
 ?
3.6.1.6 CDP + H2O
-
 Pyrobaculum aerophilum DSM 7523 CMP + phosphate
-
 ?
3.6.1.6 CDP + H2O
-
 Pyrobaculum aerophilum IM2 CMP + phosphate
-
 ?
3.6.1.6 CDP + H2O
-
 Pyrobaculum aerophilum NBRC 100827 CMP + phosphate
-
 ?
3.6.1.6 CDP + H2O
-
 Pyrobaculum aerophilum ATCC 51768 CMP + phosphate
-
 ?
3.6.1.6 CDP + H2O
-
 Pyrobaculum aerophilum JCM 9630 CMP + phosphate
-
 ?
3.6.1.6 dADP + H2O very low activity Thermus thermophilus dAMP + phosphate
-
 ?
3.6.1.6 dGDP + H2O very low activity Thermus thermophilus dGMP + phosphate
-
 ?
3.6.1.6 GDP + H2O very low activity Thermus thermophilus GMP + phosphate
-
 ?
3.6.1.6 GDP + H2O very low activity Thermus thermophilus DSM 579 GMP + phosphate
-
 ?
3.6.1.6 GDP + H2O very low activity Thermus thermophilus ATCC 27634 GMP + phosphate
-
 ?
3.6.1.6 additional information the TTHA1091 protein does not possess ADK activity but instead possesses adenosine diphosphatase (ADPase) activity Thermus thermophilus ?
-
-
3.6.1.6 additional information the enzyme encoded by TTHA1091 shows degradation of ADP to AMP and thus possesses adenosine diphosphatase (ADPase) activity, but it does not catalyse the phosphorylation of adenosine when ATP or ADP are used as phosphate donors. The ADPase activity is specific for ADP and CDP. No or poor activity with UDP, TDP, and dCDP, substrate specificity, overview Thermus thermophilus ?
-
-
3.6.1.6 additional information the TTHA1091 protein does not possess ADK activity but instead possesses adenosine diphosphatase (ADPase) activity Thermus thermophilus DSM 579 ?
-
-
3.6.1.6 additional information the enzyme encoded by TTHA1091 shows degradation of ADP to AMP and thus possesses adenosine diphosphatase (ADPase) activity, but it does not catalyse the phosphorylation of adenosine when ATP or ADP are used as phosphate donors. The ADPase activity is specific for ADP and CDP. No or poor activity with UDP, TDP, and dCDP, substrate specificity, overview Thermus thermophilus DSM 579 ?
-
-
3.6.1.6 additional information the TTHA1091 protein does not possess ADK activity but instead possesses adenosine diphosphatase (ADPase) activity Thermus thermophilus ATCC 27634 ?
-
-
3.6.1.6 additional information the enzyme encoded by TTHA1091 shows degradation of ADP to AMP and thus possesses adenosine diphosphatase (ADPase) activity, but it does not catalyse the phosphorylation of adenosine when ATP or ADP are used as phosphate donors. The ADPase activity is specific for ADP and CDP. No or poor activity with UDP, TDP, and dCDP, substrate specificity, overview Thermus thermophilus ATCC 27634 ?
-
-

Synonyms

EC Number Synonyms Comment Organism
3.6.1.6 adenosine diphosphatase
-
 Pyrobaculum aerophilum
3.6.1.6 adenosine diphosphatase
-
 Thermus thermophilus
3.6.1.6 ADPase
-
 Pyrobaculum aerophilum
3.6.1.6 ADPase
-
 Thermus thermophilus
3.6.1.6 PAE2307
-
 Pyrobaculum aerophilum
3.6.1.6 TTHA1091
-
 Thermus thermophilus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.6.1.6 70
-
 assay at Thermus thermophilus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.6.1.6 8
-
 assay at Thermus thermophilus

General Information

EC Number General Information Comment Organism
3.6.1.6 evolution the enzyme is a family member of the COG1839 family, defined as adenosine-specific kinase family based on structural analysis and the adenosine-binding ability Pyrobaculum aerophilum
3.6.1.6 evolution the enzyme is a family member of the COG1839 family, defined as adenosine-specific kinase family based on structural analysis and the adenosine-binding ability Thermus thermophilus
3.6.1.6 additional information structure comparison of homologous structures of TTHA1091 protein (PDB ID 1VGG) and PAE2307 protein (PDB ID 1WVQ, from Pyrobaculum aerophilum strain ATCC 51768), overview. The model structure also suggests that the beta-phosphate group of ADP (and CDP) can be located near His80 Thermus thermophilus
3.6.1.6 additional information structure comparison of homologous structures of TTHA1091 protein (PDB ID 1VGG, from Thermus thermophilus strain HB8) and PAE2307 protein (PDB ID 1WVQ), overview. The model structure also suggests that the beta-phosphate group of ADP (and CDP) can be located near His80 Pyrobaculum aerophilum