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Literature summary extracted from

  • Kumar, V.; Sharma, A.; Pratap, S.; Kumar, P.
    Biophysical and in silico interaction studies of aporphine alkaloids with malonyl-CoA ACP transacylase (FabD) from drug resistant Moraxella catarrhalis (2018), Biochimie, 149, 18-33 .
    View publication on PubMed

Application

EC Number Application Comment Organism
2.3.1.39 drug development the enzyme is a target for developing broad-spectrum antibiotics Moraxella catarrhalis

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.1.39 apomorphine
-
 Moraxella catarrhalis
2.3.1.39 boldine
-
 Moraxella catarrhalis
2.3.1.39 corytuberine
-
 Moraxella catarrhalis
2.3.1.39 magnoflorine
-
 Moraxella catarrhalis

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.39 malonyl-CoA + an [acyl-carrier protein] Moraxella catarrhalis
-
 CoA + a malonyl-[acyl-carrier protein]
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.39 Moraxella catarrhalis
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.39 malonyl-CoA + an [acyl-carrier protein]
-
 Moraxella catarrhalis CoA + a malonyl-[acyl-carrier protein]
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.3.1.39 FabD
-
 Moraxella catarrhalis
2.3.1.39 malonyl-CoA:ACP transacylase
-
 Moraxella catarrhalis

General Information

EC Number General Information Comment Organism
2.3.1.39 metabolism the enzyme is an essential enzyme of the fatty acid synthesis II pathway. It performs initiation reaction to form malonyl-ACP, which is a key building block in fatty acid biosynthesis. Aporphine alkaloids can act as antibacterial agents and possible target of these compounds could be the FabD enzyme Moraxella catarrhalis