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Literature summary extracted from

  • Salazar-Gonzalez, R.A.; Turijan-Espinoza, E.; Hein, D.W.; Nino-Moreno, P.C.; Romano-Moreno, S.; Milan-Segovia, R.C.; Portales-Perez, D.P.
    Arylamine N-acetyltransferase 1 in situ N-acetylation on CD3+ peripheral blood mononuclear cells correlate with NATb mRNA and NAT1 haplotype (2018), Arch. Toxicol., 92, 661-668 .
    View publication on PubMed

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.5 Homo sapiens P18440
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Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.5 culture condition:CD19+ cell NAT1-specific protein expression is higher in CD3+ cells than in CD19 or CD56 cells Homo sapiens
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2.3.1.5 culture condition:CD3+ cell NAT1-specific protein expression is higher in CD3+ cells than in CD19 or CD56 cells Homo sapiens
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2.3.1.5 culture condition:CD56+ cell NAT1-specific protein expression is higher in CD3+ cells than in CD19 or CD56 cells Homo sapiens
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2.3.1.5 peripheral blood mononuclear cell
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 Homo sapiens
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.5 acetyl-CoA + 4-aminobenzoate
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 Homo sapiens CoA + N-acetyl-4-aminobenzoate
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 ?

General Information

EC Number General Information Comment Organism
2.3.1.5 physiological function N-acetylation of 4-aminobenzoate varies markedly among the peripheral mononuclear blood cells of donors, but correlate very significantly with levels of NAT1 transcripts. Allelic variation NAT1*4 subjects show significantly higher apparent 4-aminobenzoate Vmax of 71.3 versus the NAT1*14B subjects apparent Vmax of 58.5 nmoles N-acetyl 4-aminobenzoate/24 h/million cells. Levels of 4-aminobenzoate N-acetylation activity at each concentration of substrate evaluated also significantly correlate with NAT1 mRNA levels for all samples Homo sapiens