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Literature summary extracted from

  • Zhang, Y.; Wei, W.; Fan, J.; Jin, C.; Lu, L.; Fang, W.
    Aspergillus fumigatus mitochondrial acetyl coenzyme A acetyltransferase as an antifungal target (2020), Appl. Environ. Microbiol., 86, e02986 .
    View publication on PubMed

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
2.3.1.9 structure of Erg10A and its complex with CoA, four substitutions within the CoA binding site are different from human orthologues Aspergillus fumigatus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.3.1.9 0.026
-
 CoA pH 8.1, 30°C Aspergillus fumigatus
2.3.1.9 0.043
-
 acetoacetyl-CoA pH 8.1, 30°C Aspergillus fumigatus
2.3.1.9 0.232
-
 acetyl-CoA pH 8.1, 30°C Aspergillus fumigatus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.3.1.9 mitochondrion
-
 Aspergillus fumigatus 5739
-

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.9 Aspergillus fumigatus B0XMC1
-
-
2.3.1.9 Aspergillus fumigatus CEA10 B0XMC1
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.9 2 acetyl-CoA
-
 Aspergillus fumigatus CoA + acetoacetyl-CoA
-
 r
2.3.1.9 2 acetyl-CoA
-
 Aspergillus fumigatus CEA10 CoA + acetoacetyl-CoA
-
 r
2.3.1.9 CoA + acetoacetyl-CoA
-
 Aspergillus fumigatus 2 acetyl-CoA
-
 r
2.3.1.9 CoA + acetoacetyl-CoA
-
 Aspergillus fumigatus CEA10 2 acetyl-CoA
-
 r
2.3.1.9 additional information Erg10A is a functional acetyl-CoA acetyltransferase catalyzing both synthetic and degradative reactions Aspergillus fumigatus ?
-
-
2.3.1.9 additional information Erg10A is a functional acetyl-CoA acetyltransferase catalyzing both synthetic and degradative reactions Aspergillus fumigatus CEA10 ?
-
-

Synonyms

EC Number Synonyms Comment Organism
2.3.1.9 AFUB_000550
-
 Aspergillus fumigatus
2.3.1.9 Erg10A
-
 Aspergillus fumigatus

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
2.3.1.9 3
-
 acetoacetyl-CoA pH 8.1, 30°C Aspergillus fumigatus
2.3.1.9 5
-
 CoA pH 8.1, 30°C Aspergillus fumigatus
2.3.1.9 7
-
 acetyl-CoA pH 8.1, 30°C Aspergillus fumigatus

General Information

EC Number General Information Comment Organism
2.3.1.9 physiological function Erg10A is essential for the survival of Neosartoya fumigata. The reduced expression of Erg10A leads to severe morphological defects and increased susceptibility to oxidative and cell wall stresses Aspergillus fumigatus