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Literature summary extracted from

  • Braga, D.; Last, D.; Hasan, M.; Guo, H.; Leichnitz, D.; Uzum, Z.; Richter, I.; Schalk, F.; Beemelmanns, C.; Hertweck, C.; Lackner, G.
    Metabolic pathway rerouting in Paraburkholderia rhizoxinica evolved long-overlooked derivatives of coenzyme F420 (2019), ACS Chem. Biol., 14, 2088-2094 .
    View publication on PubMed

Application

EC Number Application Comment Organism
2.7.7.105 synthesis the 3PG-F420 biosynthetic gene cluster is fully functional in Escherichia coli, enabling convenient production of the cofactor by fermentation Methanocaldococcus jannaschii
2.7.7.105 synthesis the 3PG-F420 biosynthetic gene cluster is fully functional in Escherichia coli, enabling convenient production of the cofactor by fermentation Mycetohabitans rhizoxinica
2.7.7.106 synthesis the 3PG-F420 biosynthetic gene cluster is fully functional in Escherichia coli, enabling convenient production of the cofactor by fermentation Mycetohabitans rhizoxinica

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.7.105 expression in Escherichia coli Methanocaldococcus jannaschii
2.7.7.105 expression in Escherichia coli Mycetohabitans rhizoxinica
2.7.7.106 expression in Escherichia coli Mycetohabitans rhizoxinica

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.7.105 phosphoenolpyruvate + GTP Methanocaldococcus jannaschii
-
 enolpyruvoyl-2-diphospho-5'-guanosine + diphosphate
-
 ?
2.7.7.105 phosphoenolpyruvate + GTP Mycetohabitans rhizoxinica
-
 enolpyruvoyl-2-diphospho-5'-guanosine + diphosphate
-
 ?
2.7.7.105 phosphoenolpyruvate + GTP Methanocaldococcus jannaschii ATCC 43067
-
 enolpyruvoyl-2-diphospho-5'-guanosine + diphosphate
-
 ?
2.7.7.106 3-phospho-D-glycerate + GTP Mycetohabitans rhizoxinica
-
 3-(D-glyceryl)-diphospho-5'-guanosine + diphosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.7.105 Methanocaldococcus jannaschii Q58297
-
-
2.7.7.105 Methanocaldococcus jannaschii ATCC 43067 Q58297
-
-
2.7.7.105 Mycetohabitans rhizoxinica
-
-
-
2.7.7.106 Mycetohabitans rhizoxinica
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.7.105 additional information CofC from Methanocaldococcus jannaschii accepts 2-phospholactate (96.5%, reaction of EC 2.7.7.68), and phosphoenolpyruvate (3.5%) Methanocaldococcus jannaschii ?
-
-
2.7.7.105 additional information CofC from Paraburkholderia rhizoxinica accepts 3-phosphoglycerate (72.7%), 2-phospholactate (23.4%), and phosphoenolpyruvate (3.9%) Mycetohabitans rhizoxinica ?
-
-
2.7.7.105 additional information CofC from Methanocaldococcus jannaschii accepts 2-phospholactate (96.5%, reaction of EC 2.7.7.68), and phosphoenolpyruvate (3.5%) Methanocaldococcus jannaschii ATCC 43067 ?
-
-
2.7.7.105 phosphoenolpyruvate + GTP
-
 Methanocaldococcus jannaschii enolpyruvoyl-2-diphospho-5'-guanosine + diphosphate
-
 ?
2.7.7.105 phosphoenolpyruvate + GTP
-
 Mycetohabitans rhizoxinica enolpyruvoyl-2-diphospho-5'-guanosine + diphosphate
-
 ?
2.7.7.105 phosphoenolpyruvate + GTP
-
 Methanocaldococcus jannaschii ATCC 43067 enolpyruvoyl-2-diphospho-5'-guanosine + diphosphate
-
 ?
2.7.7.106 3-phospho-D-glycerate + GTP
-
 Mycetohabitans rhizoxinica 3-(D-glyceryl)-diphospho-5'-guanosine + diphosphate
-
 ?
2.7.7.106 additional information CofC from Paraburkholderia rhizoxinica accepts 3-phosphoglycerate (72.7%), 2-phospholactate (23.4%), and phosphoenolpyruvate (3.9%, reaction of EC 2.7.7.106) Mycetohabitans rhizoxinica ?
-
-

Synonyms

EC Number Synonyms Comment Organism
2.7.7.105 cofC
-
 Methanocaldococcus jannaschii
2.7.7.105 cofC
-
 Mycetohabitans rhizoxinica
2.7.7.105 fbiD
-
 Methanocaldococcus jannaschii
2.7.7.105 fbiD
-
 Mycetohabitans rhizoxinica
2.7.7.106 cofC
-
 Mycetohabitans rhizoxinica
2.7.7.106 fbiD
-
 Mycetohabitans rhizoxinica