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Literature summary extracted from

  • Paiva, P.; Sousa, S.; Ramos, M.; Fernandes, P.
    Understanding the catalytic machinery and the reaction pathway of the malonyl-acetyl transferase domain of human fatty acid synthase (2018), ACS Catal., 8, 4860-4872 .
No PubMed abstract available

Protein Variants

EC Number Protein Variants Comment Organism
2.3.1.39 R606A the mutation severely impairs the malonyl transfer reaction, while leading to a kinetic improvement of the transferase activity for acetyl-CoA Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.39 acetyl-CoA + an [acyl-carrier protein] Homo sapiens
-
 CoA + an acetyl-[acyl-carrier protein]
-
 ?
2.3.1.39 malonyl-CoA + an [acyl-carrier protein] Homo sapiens
-
 CoA + a malonyl-[acyl-carrier protein]
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.39 Homo sapiens P49327
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.39 acetyl-CoA + an [acyl-carrier protein]
-
 Homo sapiens CoA + an acetyl-[acyl-carrier protein]
-
 ?
2.3.1.39 malonyl-CoA + an [acyl-carrier protein]
-
 Homo sapiens CoA + a malonyl-[acyl-carrier protein]
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.3.1.39 FAS
-
 Homo sapiens
2.3.1.39 fatty acid synthase
-
 Homo sapiens
2.3.1.39 MAT malonyl-acetyl transferase domain of fatty acid synthase Homo sapiens