Literature summary extracted from

John, S.; Aniemeke, E.; Ha, N.; Chong, C.; Gu, P.; Zhou, J.; Zhang, Y.; Graviss, E.; Liu, J.; Olaleye, O.
Characterization of 2-hydroxy-1-naphthaldehyde isonicotinoyl hydrazone as a novel inhibitor of methionine aminopeptidases from Mycobacterium tuberculosis (2016), Tuberculosis, 101, S73-S77 .

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
3.4.11.18	2-hydroxy-1-naphthaldehyde isonicotinoyl hydrazone	inhibitor of HIV-1 replication and transcription, and potent and selective inhibitor of isoforms MetAP1a and MetAP1c. The inhibitor is active against replicating and aged non-growing Micobacterium tuberculosis at low micromolar concentrations	Mycobacterium tuberculosis

Organism

EC Number	Organism	UniProt	Comment	Textmining
3.4.11.18	Mycobacterium tuberculosis	-	-	-

Synonyms

EC Number	Synonyms	Comment	Organism
3.4.11.18	MetAP1a	-	Mycobacterium tuberculosis
3.4.11.18	MetAP1c	-	Mycobacterium tuberculosis

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Release 2023.1 (January 2023)