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Literature summary extracted from
- Identification and structural characterization of LytU, a unique peptidoglycan endopeptidase from the lysostaphin family (2017), Sci. Rep., 7, 6020 .
Application
| EC Number | Application | Comment | Organism |
|---|---|---|---|
| 3.4.24.75 | medicine | the enzyme is a potential antimicrobial agent for Staphylococcus aureus infections | Staphylococcus aureus |
Cloned(Commentary)
| EC Number | Cloned (Comment) | Organism |
|---|---|---|
| 3.4.24.75 | expressed in Escherichia coli BL21(DE3) cells | Staphylococcus aureus |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.4.24.75 | Zn2+ | binding of a second zinc ion effectively inhibits the enzyme | Staphylococcus aureus |  |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 3.4.24.75 | plasma membrane | - |
Staphylococcus aureus | 5886 | - |
Metals/Ions
| EC Number | Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.4.24.75 | Zn2+ | dependent on | Staphylococcus aureus | |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.24.75 | pentaglycine + H2O | Staphylococcus aureus | - |
diglycine + triglycine | - |
? | |
| 3.4.24.75 | pentaglycine + H2O | Staphylococcus aureus NCTC 8325 | - |
diglycine + triglycine | - |
? | |
| 3.4.24.75 | Staphylococcus aureus cell wall + H2O | Staphylococcus aureus | - |
? | - |
? | |
| 3.4.24.75 | Staphylococcus aureus cell wall + H2O | Staphylococcus aureus NCTC 8325 | - |
? | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.4.24.75 | Staphylococcus aureus | - |
- |
- |
| 3.4.24.75 | Staphylococcus aureus NCTC 8325 | - |
- |
- |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.24.75 | pentaglycine + H2O | - |
Staphylococcus aureus | diglycine + triglycine | - |
? | |
| 3.4.24.75 | pentaglycine + H2O | - |
Staphylococcus aureus NCTC 8325 | diglycine + triglycine | - |
? | |
| 3.4.24.75 | Staphylococcus aureus cell wall + H2O | - |
Staphylococcus aureus | ? | - |
? | |
| 3.4.24.75 | Staphylococcus aureus cell wall + H2O | - |
Staphylococcus aureus NCTC 8325 | ? | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 3.4.24.75 | LytU | - |
Staphylococcus aureus |
| 3.4.24.75 | peptidoglycan endopeptidase | - |
Staphylococcus aureus |
| 3.4.24.75 | sa0205 | - |
Staphylococcus aureus |
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Release 2023.1 (January 2023)
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