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Literature summary extracted from

  • Peng, P.; Wu, W.; Zhao, J.; Song, S.; Wang, X.; Jia, D.; Shao, M.; Zhang, M.; Li, L.; Wang, L.; Duan, F.; Zhao, R.; Yang, C.; Wu, H.; Zhang, J.; Shen, Z.; Ruan, Y.; Gu, J.
    Decreased expression of Calpain-9 predicts unfavorable prognosis in patients with gastric cancer (2016), Sci. Rep., 6, 29604.
    View publication on PubMed

Application

EC Number Application Comment Organism
3.4.22.B28 medicine calpain-9 is generally decreased in gastric cancer cell lines and primary tumor tissues, while calpain-8 expression is not significantly altered. Calpain-9, but not calpain-8, induces cell cycle arrest at the G1 phase and cellular apoptosis in gastric cancer cells Homo sapiens
3.4.22.B28 medicine calpain-9 is generally decreased in gastric cancer cell lines and primary tumor tissues, while calpain-8 expression is not significantly altered. Calpain-9 induces cell cycle arrest in the G1 phase and cellular apoptosis in vitro, and it attenuates the growth of subcutaneous tumor xenografts in vivo. Low expression of calpain-9 is positively associated with male sex, late T stage, lymph node metastasis, and advanced TNM stage (tumor, node, metastasis). Calpain-9 is an independent prognostic factor for poor prognosis, and combining calpain-9 with TNM stage generates a better predictive model for patient outcomes Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.4.22.B28 Homo sapiens O14815
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3.4.22.B28 Homo sapiens A6NHC0
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Synonyms

EC Number Synonyms Comment Organism
3.4.22.B28 Capn8
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 Homo sapiens
3.4.22.B28 CAPN9
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 Homo sapiens