Literature summary extracted from

Guan, M.; Su, L.; Yuan, Y.C.; Li, H.; Chow, W.A.
Nelfinavir and nelfinavir analogs block site-2 protease cleavage to inhibit castration-resistant prostate cancer (2015), Sci. Rep., 5, 9698 .

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
3.4.24.85	(2E)-N-(2-[[3-(3-methyl-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]dec-8-yl)propyl]sulfanyl]phenyl)-3-phenylprop-2-enamide	-	Homo sapiens
3.4.24.85	(2E)-N-(2-[[3-(3-methyl-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]dec-8-yl)propyl]sulfanyl]phenyl)-3-phenylprop-2-enamide	-	Methanocaldococcus jannaschii
3.4.24.85	1,10-phenanthroline	-	Homo sapiens
3.4.24.85	1,10-phenanthroline	-	Methanocaldococcus jannaschii
3.4.24.85	1-[(benzoylamino)methyl]-1-[3-(benzylsulfanyl)-1-methoxy-1-oxopropan-2-yl]-4-[(benzylsulfanyl)methyl]-2,5-dioxoimidazolidin-1-ium	-	Homo sapiens
3.4.24.85	1-[(benzoylamino)methyl]-1-[3-(benzylsulfanyl)-1-methoxy-1-oxopropan-2-yl]-4-[(benzylsulfanyl)methyl]-2,5-dioxoimidazolidin-1-ium	-	Methanocaldococcus jannaschii
3.4.24.85	3-(butan-2-yl)-8-[3-[(4-fluorophenyl)sulfanyl]propyl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one	-	Homo sapiens
3.4.24.85	3-(butan-2-yl)-8-[3-[(4-fluorophenyl)sulfanyl]propyl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one	-	Methanocaldococcus jannaschii
3.4.24.85	7,8-dimethoxy-1,2,3,11a-tetrahydro-5H,11H-pyrrolo[2,1-c][1,4]benzothiazepine-5,11-dione	-	Homo sapiens
3.4.24.85	7,8-dimethoxy-1,2,3,11a-tetrahydro-5H,11H-pyrrolo[2,1-c][1,4]benzothiazepine-5,11-dione	-	Methanocaldococcus jannaschii
3.4.24.85	methyl 4-[[4-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-3-oxobutyl]sulfanyl]benzoate	-	Homo sapiens
3.4.24.85	methyl 4-[[4-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-3-oxobutyl]sulfanyl]benzoate	-	Methanocaldococcus jannaschii
3.4.24.85	nelfinavir	nelfinavir is a more potent inhibitor of CED-9 protein cleavage than 1,10-phenanthroline	Homo sapiens
3.4.24.85	nelfinavir	nelfinavir is a more potent inhibitor of CED-9 protein cleavage than 1,10-phenanthroline	Methanocaldococcus jannaschii

Organism

EC Number	Organism	UniProt	Comment	Textmining
3.4.24.85	Homo sapiens	-	-	-
3.4.24.85	Methanocaldococcus jannaschii	Q57837	-	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
3.4.24.85	DU-145 cell	-	Homo sapiens	-
3.4.24.85	PC-3 cell	-	Homo sapiens	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
3.4.24.85	ATF6 protein + H2O	-	Homo sapiens	?	-	?
3.4.24.85	ATF6 protein + H2O	-	Methanocaldococcus jannaschii	?	-	?
3.4.24.85	CED-9 protein + H2O	-	Homo sapiens	?	-	?
3.4.24.85	CED-9 protein + H2O	-	Methanocaldococcus jannaschii	?	-	?
3.4.24.85	CREBH + H2O	-	Homo sapiens	?	-	?
3.4.24.85	CREBH + H2O	-	Methanocaldococcus jannaschii	?	-	?
3.4.24.85	SREBP-1 + H2O	-	Homo sapiens	?	-	?
3.4.24.85	SREBP-1 + H2O	-	Methanocaldococcus jannaschii	?	-	?

Synonyms

EC Number	Synonyms	Comment	Organism
3.4.24.85	S2P	-	Homo sapiens
3.4.24.85	S2P	-	Methanocaldococcus jannaschii
3.4.24.85	site-2 protease	-	Homo sapiens
3.4.24.85	site-2 protease	-	Methanocaldococcus jannaschii

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Release 2023.1 (January 2023)