EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
3.4.21.B6 | Drosophila melanogaster | Q9W2C8 | - |
- |
3.4.21.109 | Drosophila melanogaster | A1Z7M3 | isoform A | - |
EC Number | Posttranslational Modification | Comment | Organism |
---|---|---|---|
3.4.21.B6 | proteolytic modification | the zymogen in vitro is activated by notopleural | Drosophila melanogaster |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.4.21.B6 | dumpy + H2O | i.e. a zona pellucida-domain protein | Drosophila melanogaster | ? | - |
? | |
3.4.21.109 | dumpy + H2O | i.e. a zona pellucida-domain protein | Drosophila melanogaster | ? | - |
? | |
3.4.21.109 | tracheal-prostasin zymogen + H2O | - |
Drosophila melanogaster | ? | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
3.4.21.B6 | LD47230p | - |
Drosophila melanogaster |
3.4.21.B6 | tracheal-prostasin | - |
Drosophila melanogaster |
3.4.21.109 | notopleural | - |
Drosophila melanogaster |
EC Number | General Information | Comment | Organism |
---|---|---|---|
3.4.21.B6 | physiological function | tracheal-prostasin is a functional homologue of prostasin. Tracheal-prostasin degrades the zona pellucida-domain protein Dumpy, a component of the transient tracheal apical extracellular matrix. The tracheal-prostasin zymogen in vitro is activated by notopleural. RNAi-mediated knockdown embryos lack tracheal liquid clearance and die during the first instar larval stage | Drosophila melanogaster |
3.4.21.109 | physiological function | notopleural is a functional homologue of matriptase. Notopleural mediates morphogeneisis and remodeling of apical extracellular matrix during tracheal system development and is essential for maintenance of the transepithelial barrier function. Notopleural degrades the zona pellucida-domain protein Dumpy, a component of the transient tracheal apical extracellular matrix. Notopleural cleaves tracheal-prostasin zymogen and the zona pellucida-domain of the extracellular matrix protein Piopio in vitro | Drosophila melanogaster |