EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.1.1.355 | 3 S-adenosyl-L-methionine + a [histone H3]-L-lysine9 | Drosophila melanogaster | overall reaction | 3 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine9 | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.1.1.355 | Drosophila melanogaster | - |
- |
- |
2.1.1.355 | Drosophila melanogaster | Q32KD2 | - |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
2.1.1.355 | germ cell | - |
Drosophila melanogaster | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.1.1.355 | 3 S-adenosyl-L-methionine + a [histone H3]-L-lysine9 | overall reaction | Drosophila melanogaster | 3 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine9 | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
2.1.1.355 | H3K9 methyltransferase | - |
Drosophila melanogaster |
2.1.1.355 | SETDB1 | - |
Drosophila melanogaster |
EC Number | General Information | Comment | Organism |
---|---|---|---|
2.1.1.355 | malfunction | enzyme loss blocks germ cell differentiation | Drosophila melanogaster |
2.1.1.355 | physiological function | female identity is secured by an H3K9me3 epigenetic pathway in which Sxl is the upstream female-specific regulator, SETDB1 is the required chromatin writer, and phf7 is one of the critical SETDB1 target genes. Germ cell specific loss of the H3K9me3 pathway members, the H3K9 methyltransferase SETDB1, WDE, and HP1a, leads to ectopic expression of genes, many of which are normally expressed in testis. SETDB1 controls the accumulation of H3K9me3 over a subset of these genes without spreading into neighboring loci | Drosophila melanogaster |