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Literature summary extracted from

  • Lin, C.H.; Li, B.; Swanson, S.; Zhang, Y.; Florens, L.; Washburn, M.P.; Abmayr, S.M.; Workman, J.L.
    Heterochromatin protein 1a stimulates histone H3 lysine 36 demethylation by the Drosophila KDM4A demethylase (2008), Mol. Cell, 32, 696-706 .
    View publication on PubMedView publication on EuropePMC

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.11.69 [histone H3]-N6,N6,N6-trimethyllysine36 + 2 2-oxoglutarate + 2 O2 Drosophila melanogaster
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 [histone H3]-N6-methyllysine36 + 2 succinate + 2 formaldehyde + 2 CO2
-
 ?
1.14.11.69 [histone H3]-N6,N6,N6-trimethyllysine36 + 2-oxoglutarate + O2 Drosophila melanogaster
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 [histone H3]-N6,N6-dimethyllysine36 + succinate + formaldehyde + CO2
-
 ?
1.14.11.69 [histone H3]-N6,N6-dimethyllysine36 + 2-oxoglutarate + O2 Drosophila melanogaster
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 [histone H3]-N6-methyllysine36 + succinate + formaldehyde + CO2
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.14.11.69 Drosophila melanogaster Q9V333
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.11.69 [histone H3]-N6,N6,N6-trimethyllysine36 + 2 2-oxoglutarate + 2 O2
-
 Drosophila melanogaster [histone H3]-N6-methyllysine36 + 2 succinate + 2 formaldehyde + 2 CO2
-
 ?
1.14.11.69 [histone H3]-N6,N6,N6-trimethyllysine36 + 2-oxoglutarate + O2
-
 Drosophila melanogaster [histone H3]-N6,N6-dimethyllysine36 + succinate + formaldehyde + CO2
-
 ?
1.14.11.69 [histone H3]-N6,N6-dimethyllysine36 + 2-oxoglutarate + O2
-
 Drosophila melanogaster [histone H3]-N6-methyllysine36 + succinate + formaldehyde + CO2
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.11.69 KDM4A,
-
 Drosophila melanogaster

General Information

EC Number General Information Comment Organism
1.14.11.69 physiological function KDM4A specifically demethylates H3K36me2 and me3 both in vitro and in vivo. Heterochromatin Protein 1a (HP1a) associates with KDMA4A. The chromoshadow domain of HP1a and a HP1-interacting motif of KDM4A are responsible for this interaction. HP1a stimulates the histone H3K36 demethylation activity of dKDM4A. Loss of HP1a leads to increased level of histone H3K36me3 Drosophila melanogaster