Literature summary extracted from

Khrenova, M.G.; Kots, E.D.; Varfolomeev, S.D.; Lushchekina, S.V.; Nemukhin, A.V.
Three faces of N-acetylaspartate activator, substrate, and inhibitor of human aspartoacylase (2017), J. Phys. Chem. B, 121, 9389-9397 .

Activating Compound

EC Number	Activating Compound	Comment	Organism	Structure
3.5.1.15	N-acetylaspartate	N-acetylaspartate acts as activator at low concentrations, substrate at moderate concentrations, and inhibitor at high concentrations	Homo sapiens

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
3.5.1.15	N-acetyl-L-aspartate	at low N-acetyl-L-aspartate concentrations, sigmoidal shape of kinetic curve is observed, followed by typicalrate growth of the enzyme-catalyzed reaction, whereas at high concentrations of N-acetyl-L-aspartate self-inhibition takes place. N-Acetylaspartate acts as activator at low concentrations, substrate at moderate concentrations, and inhibitor at high concentrations	Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number	Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
3.5.1.15	N-acetyl-L-aspartate + H2O	Homo sapiens	-	acetate + L-aspartate	-	?

Organism

EC Number	Organism	UniProt	Comment	Textmining
3.5.1.15	Homo sapiens	P45381	-	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
3.5.1.15	N-acetyl-L-aspartate + H2O	-	Homo sapiens	acetate + L-aspartate	-	?

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Release 2023.1 (January 2023)