Literature summary extracted from

  • Qiu, Z.C.; Dong, X.L.; Dai, Y.; Xiao, G.K.; Wang, X.L.; Wong, K.C.; Wong, M.S.; Yao, X.S.
    Discovery of a new class of cathepsin K inhibitors in Rhizoma Drynariae as potential candidates for the treatment of osteoporosis (2016), Int. J. Mol. Sci., 17, E2116 .
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.22.38 kushennol F shows inhibitory effects on the bone resorption process related to cathepsin K Homo sapiens
3.4.22.38 Phe-Phe-fluoromethylketone
-
Homo sapiens
3.4.22.38 sophoraflavanone G shows inhibitory effects on the bone resorption process related to cathepsin K Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.4.22.38 Homo sapiens P43235
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.22.38 osteoclast
-
Homo sapiens
-

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
3.4.22.38 0.000047
-
pH and temperature not specified in the publication Homo sapiens Phe-Phe-fluoromethylketone
3.4.22.38 0.0272
-
pH and temperature not specified in the publication Homo sapiens sophoraflavanone G
3.4.22.38 0.00879
-
pH and temperature not specified in the publication Homo sapiens kushennol F

General Information

EC Number General Information Comment Organism
3.4.22.38 metabolism the enzyme accounts for the increase in bone resorption in metabolic bone disorders such as postmenopausal osteoporosis Homo sapiens