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Literature summary extracted from

  • Elmwall, J.; Kwiecinski, J.; Na, M.; Ali, A.A.; Osla, V.; Shaw, L.N.; Wang, W.; Saevman, K.; Josefsson, E.; Bylund, J.; Jin, T.; Welin, A.; Karlsson, A.
    Galectin-3 is a target for proteases involved in the virulence of Staphylococcus aureus (2017), Infect. Immun., 85, e00177-17 .
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.22.48 SspC
-
 Staphylococcus aureus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.22.48 Galectin-3 + H2O Staphylococcus aureus the enzyme has galectin-3-processing capacity ?
-
 ?
3.4.22.48 Galectin-3 + H2O Staphylococcus aureus the enzyme inactivates galectin-3, abrogating its stimulation of oxygen radical production in human neutrophils and increasing tissue damage during skin infection ?
-
 ?
3.4.22.48 Galectin-3 + H2O Staphylococcus aureus NCTC 8325 the enzyme inactivates galectin-3, abrogating its stimulation of oxygen radical production in human neutrophils and increasing tissue damage during skin infection ?
-
 ?
3.4.22.48 Galectin-3 + H2O Staphylococcus aureus NCTC 8325 the enzyme has galectin-3-processing capacity ?
-
 ?
3.4.24.29 Galectin-3 + H2O Staphylococcus aureus the enzyme has galectin-3-processing capacity. It cleaves human galectin-3 (a beta-galactoside-binding lectin involved in immune regulation and antimicrobial defense) into mostly higher-molecular-mass fragments, suggesting that it primarily digested the more distant parts of the N-terminal collagen-like domain ?
-
 ?
3.4.24.29 Galectin-3 + H2O Staphylococcus aureus NCTC 8325 the enzyme has galectin-3-processing capacity. It cleaves human galectin-3 (a beta-galactoside-binding lectin involved in immune regulation and antimicrobial defense) into mostly higher-molecular-mass fragments, suggesting that it primarily digested the more distant parts of the N-terminal collagen-like domain ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.19 Staphylococcus aureus Q2FZL2
-
-
3.4.21.19 Staphylococcus aureus NCTC 8325 Q2FZL2
-
-
3.4.22.48 Staphylococcus aureus Q2FZL3
-
-
3.4.22.48 Staphylococcus aureus Q2G2R8
-
-
3.4.22.48 Staphylococcus aureus NCTC 8325 Q2FZL3
-
-
3.4.22.48 Staphylococcus aureus NCTC 8325 Q2G2R8
-
-
3.4.24.29 Staphylococcus aureus Q2FZL2
-
-
3.4.24.29 Staphylococcus aureus NCTC 8325 Q2FZL2
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.21.19 additional information the enzyme shows little or no degradation of galectin-3 Staphylococcus aureus ?
-
 ?
3.4.21.19 additional information the enzyme shows little or no degradation of galectin-3 Staphylococcus aureus NCTC 8325 ?
-
 ?
3.4.22.48 Galectin-3 + H2O the enzyme has galectin-3-processing capacity Staphylococcus aureus ?
-
 ?
3.4.22.48 Galectin-3 + H2O the enzyme inactivates galectin-3, abrogating its stimulation of oxygen radical production in human neutrophils and increasing tissue damage during skin infection Staphylococcus aureus ?
-
 ?
3.4.22.48 Galectin-3 + H2O the enzyme inactivates galectin-3, abrogating its stimulation of oxygen radical production in human neutrophils and increasing tissue damage during skin infection Staphylococcus aureus NCTC 8325 ?
-
 ?
3.4.22.48 Galectin-3 + H2O the enzyme has galectin-3-processing capacity Staphylococcus aureus NCTC 8325 ?
-
 ?
3.4.24.29 Galectin-3 + H2O the enzyme has galectin-3-processing capacity. It cleaves human galectin-3 (a beta-galactoside-binding lectin involved in immune regulation and antimicrobial defense) into mostly higher-molecular-mass fragments, suggesting that it primarily digested the more distant parts of the N-terminal collagen-like domain Staphylococcus aureus ?
-
 ?
3.4.24.29 Galectin-3 + H2O the enzyme has galectin-3-processing capacity. It cleaves human galectin-3 (a beta-galactoside-binding lectin involved in immune regulation and antimicrobial defense) into mostly higher-molecular-mass fragments, suggesting that it primarily digested the more distant parts of the N-terminal collagen-like domain Staphylococcus aureus NCTC 8325 ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.21.19 glutamyl endopeptidase
-
 Staphylococcus aureus
3.4.21.19 Sspa
-
 Staphylococcus aureus
3.4.21.19 V8 protease
-
 Staphylococcus aureus
3.4.22.48 SCPA
-
 Staphylococcus aureus
3.4.22.48 SspB
-
 Staphylococcus aureus
3.4.22.48 staphopain A
-
 Staphylococcus aureus
3.4.22.48 staphopain B
-
 Staphylococcus aureus

General Information

EC Number General Information Comment Organism
3.4.22.48 physiological function SspB is a virulence factor. Its function is dependent on the presence of galectin-3. It inactivates galectin-3, abrogating its stimulation of oxygen radical production in human neutrophils and increasing tissue damage during skin infection. The enzyme is an inhibitor of galectin-3-mediated ROS production Staphylococcus aureus