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Literature summary extracted from
- The histone demethylase Dmel\Kdm4A controls genes required for life span and male-specific sex determination in Drosophila (2009), Gene, 450, 8-17 .
Cloned(Commentary)
| EC Number | Cloned (Comment) | Organism |
|---|---|---|
| 1.14.11.66 | gene KDM4A, DNA and amino acid sequence determination and analysis, quantitative PCR expression analysis and sequence comparisons | Drosophila melanogaster |
| 1.14.11.69 | gene KDM4A, DNA and amino acid sequence determination and analysis, quantitative PCR expression analysis and sequence comparisons | Drosophila melanogaster |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 1.14.11.66 | nucleus | - |
Drosophila melanogaster | 5634 | - |
| 1.14.11.69 | nucleus | - |
Drosophila melanogaster | 5634 | - |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.14.11.66 | [histone H3]-N6,N6,N6-trimethyl-L-lysine 9 + 2-oxoglutarate + O2 | Drosophila melanogaster | - |
[histone H3]-N6,N6-dimethyl-L-lysine 9 + succinate + formaldehyde + CO2 | - |
? |  |
| 1.14.11.66 | [histone H3]-N6,N6-dimethyl-L-lysine 9 + 2-oxoglutarate + O2 | Drosophila melanogaster | - |
[histone H3]-N6-methyl-L-lysine 9 + succinate + formaldehyde + CO2 | - |
? | |
| 1.14.11.69 | [histone H3]-N6,N6,N6-trimethyl-L-lysine 36 + 2-oxoglutarate + O2 | Drosophila melanogaster | - |
[histone H3]-N6,N6-dimethyl-L-lysine 36 + succinate + formaldehyde + CO2 | - |
? | |
| 1.14.11.69 | [histone H3]-N6,N6-dimethyl-L-lysine 36 + 2-oxoglutarate + O2 | Drosophila melanogaster | - |
[histone H3]-N6-methyl-L-lysine 36 + succinate + formaldehyde + CO2 | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.14.11.66 | Drosophila melanogaster | Q9V333 | - |
- |
| 1.14.11.69 | Drosophila melanogaster | Q9V333 | - |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 1.14.11.66 | additional information | Dmel\Kdm4A expression during development in comparison to other JMJD2 enzymes, overview | Drosophila melanogaster | - |
| 1.14.11.69 | additional information | Dmel\Kdm4A expression during development in comparison to other JMJD2 enzymes, overview | Drosophila melanogaster | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.14.11.66 | additional information | the bifunctional enzyme specifically demethylates Lys9 and Lys36 (1.14.11.69) residues of histone H3 | Drosophila melanogaster | ? | - |
? | |
| 1.14.11.66 | [histone H3]-N6,N6,N6-trimethyl-L-lysine 9 + 2-oxoglutarate + O2 | - |
Drosophila melanogaster | [histone H3]-N6,N6-dimethyl-L-lysine 9 + succinate + formaldehyde + CO2 | - |
? | |
| 1.14.11.66 | [histone H3]-N6,N6-dimethyl-L-lysine 9 + 2-oxoglutarate + O2 | - |
Drosophila melanogaster | [histone H3]-N6-methyl-L-lysine 9 + succinate + formaldehyde + CO2 | - |
? | |
| 1.14.11.69 | additional information | the bifunctional enzyme specifically demethylates Lys9 (EC 1.14.11.66) and Lys36 residues of histone H3 | Drosophila melanogaster | ? | - |
? | |
| 1.14.11.69 | [histone H3]-N6,N6,N6-trimethyl-L-lysine 36 + 2-oxoglutarate + O2 | - |
Drosophila melanogaster | [histone H3]-N6,N6-dimethyl-L-lysine 36 + succinate + formaldehyde + CO2 | - |
? | |
| 1.14.11.69 | [histone H3]-N6,N6-dimethyl-L-lysine 36 + 2-oxoglutarate + O2 | - |
Drosophila melanogaster | [histone H3]-N6-methyl-L-lysine 36 + succinate + formaldehyde + CO2 | - |
? | |
Subunits
| EC Number | Subunits | Comment | Organism |
|---|---|---|---|
| 1.14.11.66 | More | histone demethylase familiy enzymes domain structure comparisons, overview | Drosophila melanogaster |
| 1.14.11.69 | More | histone demethylase familiy enzymes domain structure comparisons, overview | Drosophila melanogaster |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 1.14.11.66 | CG15835 | - |
Drosophila melanogaster |
| 1.14.11.66 | Dmel\Kdm4A | - |
Drosophila melanogaster |
| 1.14.11.66 | KDM4A | - |
Drosophila melanogaster |
| 1.14.11.66 | lysine-specific demethylase 4A | UniProt | Drosophila melanogaster |
| 1.14.11.69 | CG15835 | - |
Drosophila melanogaster |
| 1.14.11.69 | Dmel\Kdm4A | - |
Drosophila melanogaster |
| 1.14.11.69 | KDM4A | - |
Drosophila melanogaster |
| 1.14.11.69 | lysine-specific demethylase 4A | UniProt | Drosophila melanogaster |
General Information
| EC Number | General Information | Comment | Organism |
|---|---|---|---|
| 1.14.11.66 | evolution | the Drosophila melanogaster HDM gene Dmel\Kdm4A is a homologue of the human JMJD2 family. Dmel\JHMD1, Dmel\JHMD2, and Dmel\Kdm4A are each highly conserved with their human homologue counterparts | Drosophila melanogaster |
| 1.14.11.66 | malfunction | disruption of Dmel\Kdm4A results in a reduction of the male life span and a male-specific wing extension/twitching phenotype that occurs in response to other males and is reminiscent of an inter-male courtship phenotype involving the courtship song, phenotypes overview. Certain genes associated with each of these phenotypes are significantly downregulated in response to Dmel\Kdm4A loss, most notably the longevity associated Hsp22 gene and the male sex-determination fruitless gene | Drosophila melanogaster |
| 1.14.11.66 | physiological function | histone demethylase Dmel\Kdm4A controls genes required for life span and male-specific sex determination in Drosophila melanogaster. Essential role for Dmel\Kdm4A in the transcriptional activation of genes involved in the aging process and male-specific neuronal formation and courtship behavior | Drosophila melanogaster |
| 1.14.11.69 | evolution | the Drosophila melanogaster HDM gene Dmel\Kdm4A is a homologue of the human JMJD2 family. Dmel\JHMD1, Dmel\JHMD2, and Dmel\Kdm4A are each highly conserved with their human homologue counterparts | Drosophila melanogaster |
| 1.14.11.69 | malfunction | disruption of Dmel\Kdm4A results in a reduction of the male life span and a male-specific wing extension/twitching phenotype that occurs in response to other males and is reminiscent of an inter-male courtship phenotype involving the courtship song, phenotypes overview. Certain genes associated with each of these phenotypes are significantly downregulated in response to Dmel\Kdm4A loss, most notably the longevity associated Hsp22 gene and the male sex-determination fruitless gene | Drosophila melanogaster |
| 1.14.11.69 | physiological function | histone demethylase Dmel\Kdm4A controls genes required for life span and male-specific sex determination in Drosophila melanogaster. Essential role for Dmel\Kdm4A in the transcriptional activation of genes involved in the aging process and male-specific neuronal formation and courtship behavior | Drosophila melanogaster |
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