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Literature summary extracted from

  • Sun, L.; Li, X.; Shi, Y.
    Structural biology of intramembrane proteases Mechanistic insights from rhomboid and S2P to gamma-secretase (2016), Curr. Opin. Struct. Biol., 37, 97-107 .
    View publication on PubMed

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.24.85 membrane
-
 Methanocaldococcus jannaschii 16020
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.4.24.85 Zn2+ contains zinc Methanocaldococcus jannaschii

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.24.85 ATF6 protein + H2O Methanocaldococcus jannaschii
-
 ?
-
 ?
3.4.24.85 SREBP-1 + H2O Methanocaldococcus jannaschii
-
 ?
-
 ?
3.4.24.85 SREBP-2 + H2O Methanocaldococcus jannaschii
-
 ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.24.85 Methanocaldococcus jannaschii Q57837
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.24.85 ATF6 protein + H2O
-
 Methanocaldococcus jannaschii ?
-
 ?
3.4.24.85 additional information in most cases, substrate cleavage by the enzyme requires a preceding truncation of the same substrate by another aqueous protease Methanocaldococcus jannaschii ?
-
 ?
3.4.24.85 SREBP-1 + H2O
-
 Methanocaldococcus jannaschii ?
-
 ?
3.4.24.85 SREBP-2 + H2O
-
 Methanocaldococcus jannaschii ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.24.85 S2P
-
 Methanocaldococcus jannaschii
3.4.24.85 site-2 metalloprotease
-
 Methanocaldococcus jannaschii