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Literature summary extracted from

  • He, J.; Hertweck, C.
    Functional analysis of the aureothin iterative type I polyketide syntase (2005), ChemBioChem, 6, 908-912 .
    View publication on PubMed

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.289 Streptomyces thioluteus Q70KH8 and Q70KH5 and Q70KH4 Q70KH8 i.e. subunit AurA, Q70KH5 i.e. subunit AurB, Q70KH4 i.e. subunit AurC
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2.3.1.289 Streptomyces thioluteus HKI-227 Q70KH8 and Q70KH5 and Q70KH4 Q70KH8 i.e. subunit AurA, Q70KH5 i.e. subunit AurB, Q70KH4 i.e. subunit AurC
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.289 4-nitrobenzoyl-CoA + malonyl-CoA + 4 (S)-methylmalonyl-CoA + 4 NADPH + 4 H+
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 Streptomyces thioluteus demethylluteothin + 5 CO2 + 6 CoA + 4 NADP+ + 3 H2O
-
 ?
2.3.1.289 4-nitrobenzoyl-CoA + malonyl-CoA + 4 (S)-methylmalonyl-CoA + 4 NADPH + 4 H+
-
 Streptomyces thioluteus HKI-227 demethylluteothin + 5 CO2 + 6 CoA + 4 NADP+ + 3 H2O
-
 ?

General Information

EC Number General Information Comment Organism
2.3.1.289 physiological function heterologous expression of an engineered AurAB fusion protein. Inactivation the ketosynthase or acyl carrier domains of module 4 clearly result in a shutdown of polyketide biosynthesis. Module 4 is required for the biosynthesis of polyketide production, and, despite the apparently inactive AT4 domain, an iterative use of the entirety of module 3 seems not to take place Streptomyces thioluteus