EC Number | Cloned (Comment) | Organism |
---|---|---|
3.4.14.4 | expression in Escherichia coli | Homo sapiens |
EC Number | Crystallization (Comment) | Organism |
---|---|---|
3.4.14.4 | molecular dynamics simulations of the complex with luteolin. The 3' and 4' hydroxyl group on B-ring as well as 5 and 7 hydroxyl group on A-ring helps luteolin to interact with the Asn391, Asn406, Tyr417, His450, Glu451, Val447, Glu512, Asn545, Gln566, and Arg572 residues | Homo sapiens |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
3.4.14.4 | fisetin | - |
Homo sapiens | |
3.4.14.4 | galangin | - |
Homo sapiens | |
3.4.14.4 | genistein | - |
Homo sapiens | |
3.4.14.4 | kaempferol | - |
Homo sapiens | |
3.4.14.4 | luteolin | - |
Homo sapiens |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
3.4.14.4 | Homo sapiens | Q9NY33 | - |
- |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.4.14.4 | Arg-Arg-2-naphthylamide + H2O | - |
Homo sapiens | Arg-Arg + 2-naphthylamine | - |
? |
EC Number | IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|---|
3.4.14.4 | 0.022 | - |
pH 7.4, 37°C | Homo sapiens | luteolin | |
3.4.14.4 | 0.0234 | - |
pH 7.4, 37°C | Homo sapiens | galangin | |
3.4.14.4 | 0.0249 | - |
pH 7.4, 37°C | Homo sapiens | fisetin | |
3.4.14.4 | 0.0329 | - |
pH 7.4, 37°C | Homo sapiens | kaempferol | |
3.4.14.4 | 0.0366 | - |
pH 7.4, 37°C | Homo sapiens | genistein |