Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Agic, D.; Brkic, H.; Tomic, S.; Karacic, Z.; Spoljarevic, M.; Lisjak, M.; Beslo, D.; Abramic, M.
    Validation of flavonoids as potential dipeptidyl peptidase III inhibitors Experimental and computational approach (2017), Chem. Biol. Drug Des., 89, 619-627 .
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.4.14.4 expression in Escherichia coli Homo sapiens

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
3.4.14.4 molecular dynamics simulations of the complex with luteolin. The 3' and 4' hydroxyl group on B-ring as well as 5 and 7 hydroxyl group on A-ring helps luteolin to interact with the Asn391, Asn406, Tyr417, His450, Glu451, Val447, Glu512, Asn545, Gln566, and Arg572 residues Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.14.4 fisetin
-
Homo sapiens
3.4.14.4 galangin
-
Homo sapiens
3.4.14.4 genistein
-
Homo sapiens
3.4.14.4 kaempferol
-
Homo sapiens
3.4.14.4 luteolin
-
Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.4.14.4 Homo sapiens Q9NY33
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.14.4 Arg-Arg-2-naphthylamide + H2O
-
Homo sapiens Arg-Arg + 2-naphthylamine
-
?

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
3.4.14.4 0.022
-
pH 7.4, 37°C Homo sapiens luteolin
3.4.14.4 0.0234
-
pH 7.4, 37°C Homo sapiens galangin
3.4.14.4 0.0249
-
pH 7.4, 37°C Homo sapiens fisetin
3.4.14.4 0.0329
-
pH 7.4, 37°C Homo sapiens kaempferol
3.4.14.4 0.0366
-
pH 7.4, 37°C Homo sapiens genistein