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Literature summary extracted from

  • Muderrisoglu, C.; Yesil-Celiktas, O.
    High-yield biocatalysis of baicalein 7-O-beta-D-glucuronide to baicalein using soluble Helix pomatia-derived beta-glucuronidase in a chemically defined acidic Medium (2019), Catal. Lett., 149, 1701-1709 .
No PubMed abstract available

Application

EC Number Application Comment Organism
3.2.1.167 synthesis the enzyme can be used for biotransformation of glycone baicalin to more pharmacologically active aglycone baicalein in extracts from Scutellaria baicalensis Georgi plant roots. Development of a chemically defined medium-based baicalein bioproduction process with a comparable yield compared to complex medium-based ones, overview Helix pomatia

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.2.1.167 baicalin + H2O Helix pomatia
-
 baicalein + D-glucuronate
-
 ?

Organic Solvent Stability

EC Number Organic Solvent Comment Organism
3.2.1.167 dimethyl formamide enzyme HP-GUS retains its catalytic activity in presence of 5% DMF, which is required in the biotransformation assay due to a low solubility and insolubility problem of baicalin and baicalein at reaction pH 4.5, respectively Helix pomatia

Organism

EC Number Organism UniProt Comment Textmining
3.2.1.167 Helix pomatia
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.2.1.167 baicalin + H2O
-
 Helix pomatia baicalein + D-glucuronate
-
 ?
3.2.1.167 baicalin + H2O baicalein 7-O-beta-D-glucuronide Helix pomatia baicalein + D-glucuronate
-
 ?
3.2.1.167 additional information development of a chemically defined medium-based baicalein bioproduction process with a comparable yield compared to complex medium-based ones, detailed overview Helix pomatia ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.2.1.167 beta-glucuronidase
-
 Helix pomatia
3.2.1.167 GUS
-
 Helix pomatia
3.2.1.167 HP-GUS
-
 Helix pomatia

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.2.1.167 37
-
-
 Helix pomatia

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.2.1.167 4.5
-
-
 Helix pomatia