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Literature summary extracted from

  • Wang, H.; Maurer, B.J.; Reynolds, C.P.; Cabot, M.C.
    N-(4-Hydroxyphenyl)retinamide elevates ceramide in neuroblastoma cell lines by coordinate activation of serine palmitoyltransferase and ceramide synthase (2001), Cancer Res., 61, 5102-5105 .
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.3.1.24 N-(4-hydroxyphenyl)retinamide i.e. 4-HPR or fenretinide, elevates ceramide in neuroblastoma cell lines by coordinating activation of serine palmitoyltransferase and ceramide synthase. 4-HPR treatment does not accelerate cellular decay of sphingomyelin Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.1.24 fumonisin B1 a ceramide synthase inhibitor Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.3.1.24 microsome
-
 Homo sapiens
-
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.24 sphinganine + palmitoyl-CoA Homo sapiens
-
 N-palmitoyl-DL-dihydrosphingosine + CoA
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.24 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.24 CHLA-90 cell
-
 Homo sapiens
-
2.3.1.24 neuroblastoma cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.24 sphinganine + palmitoyl-CoA
-
 Homo sapiens N-palmitoyl-DL-dihydrosphingosine + CoA
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.3.1.24 ceramide synthase
-
 Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.3.1.24 37
-
 assay at Homo sapiens