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Literature summary extracted from

  • Kawai, S.; Murata, K.
    Structure and function of NAD kinase and NADP phosphatase key enzymes that regulate the intracellular balance of NAD(H) and NADP(H) (2008), Biosci. Biotechnol. Biochem., 72, 919-930 .
    View publication on PubMed

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.1.3.11 0.43
-
 D-fructose 1,6-bisphosphate pH and temperature not specified in the publication Archaeoglobus fulgidus
3.1.3.11 0.43
-
 D-fructose 1,6-bisphosphate pH and temperature not specified in the publication Methanocaldococcus jannaschii
3.1.3.11 0.73
-
 D-fructose 1,6-bisphosphate pH and temperature not specified in the publication Methanocaldococcus jannaschii
3.1.3.108 0.14
-
 NADP+ pH and temperature not specified in the publication Archaeoglobus fulgidus
3.1.3.108 0.18
-
 NADP+ pH and temperature not specified in the publication Methanocaldococcus jannaschii
3.1.3.108 0.3
-
 NADPH pH and temperature not specified in the publication Methanocaldococcus jannaschii
3.1.3.108 0.36
-
 NADPH pH and temperature not specified in the publication Archaeoglobus fulgidus
3.1.3.108 0.54
-
 NADP+ pH and temperature not specified in the publication Methanocaldococcus jannaschii
3.1.3.108 0.77
-
 NADPH pH and temperature not specified in the publication Methanocaldococcus jannaschii

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.1.23 ATP + NAD+ Methanocaldococcus jannaschii the enzyme regulates the intracellular balance of NAD(H) and NADP(H) ADP + NADP+
-
 ?
2.7.1.23 ATP + NAD+ Methanocaldococcus jannaschii ATCC 43067 the enzyme regulates the intracellular balance of NAD(H) and NADP(H) ADP + NADP+
-
 ?
3.1.3.11 D-fructose 1,6-bisphosphate + H2O Methanocaldococcus jannaschii
-
 D-fructose 6-phosphate + phosphate
-
 ?
3.1.3.11 D-fructose 1,6-bisphosphate + H2O Methanocaldococcus jannaschii ATCC 43067
-
 D-fructose 6-phosphate + phosphate
-
 ?
3.1.3.108 NADP+ + H2O Archaeoglobus fulgidus the enzyme regulates the intracellular balance of NAD(H) and NADP(H) NAD+ + phosphate
-
 ?
3.1.3.108 NADP+ + H2O Methanocaldococcus jannaschii the enzyme regulates the intracellular balance of NAD(H) and NADP(H) NAD+ + phosphate
-
 ?
3.1.3.108 NADP+ + H2O Archaeoglobus fulgidus ATCC 49558 the enzyme regulates the intracellular balance of NAD(H) and NADP(H) NAD+ + phosphate
-
 ?
3.1.3.108 NADP+ + H2O Methanocaldococcus jannaschii ATCC 43067 the enzyme regulates the intracellular balance of NAD(H) and NADP(H) NAD+ + phosphate
-
 ?
3.1.3.108 NADPH + H2O Archaeoglobus fulgidus the enzyme regulates the intracellular balance of NAD(H) and NADP(H) NADH + phosphate
-
 ?
3.1.3.108 NADPH + H2O Methanocaldococcus jannaschii the enzyme regulates the intracellular balance of NAD(H) and NADP(H) NADH + phosphate
-
 ?
3.1.3.108 NADPH + H2O Archaeoglobus fulgidus ATCC 49558 the enzyme regulates the intracellular balance of NAD(H) and NADP(H) NADH + phosphate
-
 ?
3.1.3.108 NADPH + H2O Methanocaldococcus jannaschii ATCC 43067 the enzyme regulates the intracellular balance of NAD(H) and NADP(H) NADH + phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.23 Methanocaldococcus jannaschii Q58327 cf. EC 3.1.3.108
-
2.7.1.23 Methanocaldococcus jannaschii ATCC 43067 Q58327 cf. EC 3.1.3.108
-
3.1.3.11 Archaeoglobus fulgidus O30298 cf. EC 3.1.3.108, EC 3.1.3.25
-
3.1.3.11 Archaeoglobus fulgidus ATCC 49558 O30298 cf. EC 3.1.3.108, EC 3.1.3.25
-
3.1.3.11 Methanocaldococcus jannaschii Q57573 cf. EC 3.1.3.108
-
3.1.3.11 Methanocaldococcus jannaschii Q58327 cf. EC 2.7.1.23 and EC 3.1.3.108
-
3.1.3.11 Methanocaldococcus jannaschii ATCC 43067 Q57573 cf. EC 3.1.3.108
-
3.1.3.11 Methanocaldococcus jannaschii ATCC 43067 Q58327 cf. EC 2.7.1.23 and EC 3.1.3.108
-
3.1.3.108 Archaeoglobus fulgidus O30298 cf. EC 3.1.3.11, EC 3.1.3.25
-
3.1.3.108 Archaeoglobus fulgidus ATCC 49558 O30298 cf. EC 3.1.3.11, EC 3.1.3.25
-
3.1.3.108 Methanocaldococcus jannaschii Q57573 cf. EC 3.1.3.11
-
3.1.3.108 Methanocaldococcus jannaschii Q58327 cf. EC 2.7.1.23
-
3.1.3.108 Methanocaldococcus jannaschii ATCC 43067 Q57573 cf. EC 3.1.3.11
-
3.1.3.108 Methanocaldococcus jannaschii ATCC 43067 Q58327 cf. EC 2.7.1.23
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.23 ATP + NAD+
-
 Methanocaldococcus jannaschii ADP + NADP+
-
 ?
2.7.1.23 ATP + NAD+ the enzyme regulates the intracellular balance of NAD(H) and NADP(H) Methanocaldococcus jannaschii ADP + NADP+
-
 ?
2.7.1.23 ATP + NAD+
-
 Methanocaldococcus jannaschii ATCC 43067 ADP + NADP+
-
 ?
2.7.1.23 ATP + NAD+ the enzyme regulates the intracellular balance of NAD(H) and NADP(H) Methanocaldococcus jannaschii ATCC 43067 ADP + NADP+
-
 ?
3.1.3.11 D-fructose 1,6-bisphosphate + H2O
-
 Archaeoglobus fulgidus D-fructose 6-phosphate + phosphate
-
 ?
3.1.3.11 D-fructose 1,6-bisphosphate + H2O
-
 Methanocaldococcus jannaschii D-fructose 6-phosphate + phosphate
-
 ?
3.1.3.11 D-fructose 1,6-bisphosphate + H2O
-
 Archaeoglobus fulgidus ATCC 49558 D-fructose 6-phosphate + phosphate
-
 ?
3.1.3.11 D-fructose 1,6-bisphosphate + H2O
-
 Methanocaldococcus jannaschii ATCC 43067 D-fructose 6-phosphate + phosphate
-
 ?
3.1.3.108 NADP+ + H2O
-
 Archaeoglobus fulgidus NAD+ + phosphate
-
 ?
3.1.3.108 NADP+ + H2O
-
 Methanocaldococcus jannaschii NAD+ + phosphate
-
 ?
3.1.3.108 NADP+ + H2O the enzyme regulates the intracellular balance of NAD(H) and NADP(H) Archaeoglobus fulgidus NAD+ + phosphate
-
 ?
3.1.3.108 NADP+ + H2O the enzyme regulates the intracellular balance of NAD(H) and NADP(H) Methanocaldococcus jannaschii NAD+ + phosphate
-
 ?
3.1.3.108 NADP+ + H2O
-
 Archaeoglobus fulgidus ATCC 49558 NAD+ + phosphate
-
 ?
3.1.3.108 NADP+ + H2O the enzyme regulates the intracellular balance of NAD(H) and NADP(H) Archaeoglobus fulgidus ATCC 49558 NAD+ + phosphate
-
 ?
3.1.3.108 NADP+ + H2O
-
 Methanocaldococcus jannaschii ATCC 43067 NAD+ + phosphate
-
 ?
3.1.3.108 NADP+ + H2O the enzyme regulates the intracellular balance of NAD(H) and NADP(H) Methanocaldococcus jannaschii ATCC 43067 NAD+ + phosphate
-
 ?
3.1.3.108 NADPH + H2O
-
 Archaeoglobus fulgidus NADH + phosphate
-
 ?
3.1.3.108 NADPH + H2O
-
 Methanocaldococcus jannaschii NADH + phosphate
-
 ?
3.1.3.108 NADPH + H2O the enzyme regulates the intracellular balance of NAD(H) and NADP(H) Archaeoglobus fulgidus NADH + phosphate
-
 ?
3.1.3.108 NADPH + H2O the enzyme regulates the intracellular balance of NAD(H) and NADP(H) Methanocaldococcus jannaschii NADH + phosphate
-
 ?
3.1.3.108 NADPH + H2O
-
 Archaeoglobus fulgidus ATCC 49558 NADH + phosphate
-
 ?
3.1.3.108 NADPH + H2O the enzyme regulates the intracellular balance of NAD(H) and NADP(H) Archaeoglobus fulgidus ATCC 49558 NADH + phosphate
-
 ?
3.1.3.108 NADPH + H2O
-
 Methanocaldococcus jannaschii ATCC 43067 NADH + phosphate
-
 ?
3.1.3.108 NADPH + H2O the enzyme regulates the intracellular balance of NAD(H) and NADP(H) Methanocaldococcus jannaschii ATCC 43067 NADH + phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.1.23 MJ0917
-
 Methanocaldococcus jannaschii
2.7.1.23 NAD kinase
-
 Methanocaldococcus jannaschii
3.1.3.11 AF2372
-
 Archaeoglobus fulgidus
3.1.3.11 MJ0109
-
 Methanocaldococcus jannaschii
3.1.3.11 MJ0917
-
 Methanocaldococcus jannaschii
3.1.3.108 AF2372
-
 Archaeoglobus fulgidus
3.1.3.108 MJ0109
-
 Methanocaldococcus jannaschii
3.1.3.108 MJ0917
-
 Methanocaldococcus jannaschii
3.1.3.108 NADP phosphatase
-
 Archaeoglobus fulgidus
3.1.3.108 NADP phosphatase
-
 Methanocaldococcus jannaschii
3.1.3.108 NADPase
-
 Archaeoglobus fulgidus
3.1.3.108 NADPase
-
 Methanocaldococcus jannaschii
3.1.3.108 NADPHase
-
 Archaeoglobus fulgidus
3.1.3.108 NADPHase
-
 Methanocaldococcus jannaschii

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
3.1.3.11 8.4
-
 D-fructose 1,6-bisphosphate pH and temperature not specified in the publication Methanocaldococcus jannaschii
3.1.3.11 212
-
 D-fructose 1,6-bisphosphate pH and temperature not specified in the publication Archaeoglobus fulgidus
3.1.3.11 212
-
 D-fructose 1,6-bisphosphate pH and temperature not specified in the publication Methanocaldococcus jannaschii
3.1.3.108 5
-
 NADP+ pH and temperature not specified in the publication Methanocaldococcus jannaschii
3.1.3.108 6.9
-
 NADPH pH and temperature not specified in the publication Methanocaldococcus jannaschii
3.1.3.108 26.3
-
 NADP+ pH and temperature not specified in the publication Archaeoglobus fulgidus
3.1.3.108 40.3
-
 NADPH pH and temperature not specified in the publication Archaeoglobus fulgidus
3.1.3.108 212
-
 NADP+ pH and temperature not specified in the publication Methanocaldococcus jannaschii
3.1.3.108 236
-
 NADPH pH and temperature not specified in the publication Methanocaldococcus jannaschii

General Information

EC Number General Information Comment Organism
2.7.1.23 physiological function the enzyme regulates the intracellular balance of NAD(H) and NADP(H) Methanocaldococcus jannaschii
3.1.3.11 physiological function the enzyme regulates the intracellular balance of NAD(H) and NADP(H) Methanocaldococcus jannaschii
3.1.3.108 physiological function the enzyme regulates the intracellular balance of NAD(H) and NADP(H) Archaeoglobus fulgidus
3.1.3.108 physiological function the enzyme regulates the intracellular balance of NAD(H) and NADP(H) Methanocaldococcus jannaschii

kcat/KM [mM/s]

EC Number kcat/KM Value [1/mMs-1] kcat/KM Value Maximum [1/mMs-1] Substrate Comment Organism Structure
3.1.3.11 11.6
-
 D-fructose 1,6-bisphosphate pH and temperature not specified in the publication Methanocaldococcus jannaschii
3.1.3.11 56.8
-
 D-fructose 1,6-bisphosphate pH and temperature not specified in the publication Archaeoglobus fulgidus
3.1.3.11 56.8
-
 D-fructose 1,6-bisphosphate pH and temperature not specified in the publication Methanocaldococcus jannaschii
3.1.3.108 8.9
-
 NADPH pH and temperature not specified in the publication Methanocaldococcus jannaschii
3.1.3.108 9.2
-
 NADP+ pH and temperature not specified in the publication Methanocaldococcus jannaschii
3.1.3.108 56.8
-
 NADP+ pH and temperature not specified in the publication Methanocaldococcus jannaschii
3.1.3.108 63.1
-
 NADPH pH and temperature not specified in the publication Methanocaldococcus jannaschii
3.1.3.108 113
-
 NADPH pH and temperature not specified in the publication Archaeoglobus fulgidus
3.1.3.108 188
-
 NADP+ pH and temperature not specified in the publication Archaeoglobus fulgidus